5-HT2A Receptors in the Central Nervous System

Pharmacological analysis in favour of a physiological role for the constitutive activity of 5-HT2A receptors in learning.- betaArrestins: Ligand-directed regulators of 5-HT2A receptor trafficking and signaling events.- 5-HT2A receptor heterodimerization Brain distribution.- PET imaging of the 5-HT2A receptor system: A tool to study the receptor's in vivo brain function.- Serotonergic receptor 5-HT2A in the cardiosympathovagal system.- Crosstalk between 5-HT2A and mGlu2 receptors: Implications in schizophrenia and its treatment.- Schizophrenia.- Role of Serotonin-2A Receptors in Pathophysiology and Treatment of Depression.- Brain circuits regulated by the 5-HT2A receptor: behavioural consequences on anxiety and fear memory.- 5-HT2A/2B/2C Receptors, Memory and Therapeutic Targets.- 5-HT2A receptors in the basal ganglia.- The involvement of 5-HT2A receptor in the regulation of sleep and wakefulness, and the potential therapeutic use of selective 5-HT2A receptor antagonists and inverse agonists for the treatment of an insomnia disorder.- 5-HT2A receptors and Pain.- 5-HT2A receptors in eating disorders.- Role of Serotonin2A (5-HT2A) Receptors in Epilepsy.- 5-HT2A receptors and BDNF regulation: Implications for Psychopathology.

Giuseppe Di Giovanni is Professor of Human Physiology, University of Malta, Malta. He is the President of the Malta Neuroscience Network and the Vice-President of the Mediterranean Neuroscience Society. He is the Editor in Chief of Journal Neuroscience Methods by Elsevier and the Editor for the book series The Receptor by Springer/Nature. His research focuses on the pathophysiology of the monoaminergic systems in different neuropsychiatric disorders, such as Parkinson's disease, depression, drug of abuse and epilepsy.