A Novel Synthesis Of Isotopically Labelled L-Histidine
(Sprache: Englisch)
In a few simple steps starting from a commercially available reagents benzyl chloride and potassium thiocyanate, thiocyanate is obtained which is directly reacted with glycine amide to give benzyl thiourea. The used of concentrated HCl give the ring closed...
Leider schon ausverkauft
versandkostenfrei
Buch
56.50 €
- Lastschrift, Kreditkarte, Paypal, Rechnung
- Kostenlose Rücksendung
- Ratenzahlung möglich
Produktdetails
Produktinformationen zu „A Novel Synthesis Of Isotopically Labelled L-Histidine “
Klappentext zu „A Novel Synthesis Of Isotopically Labelled L-Histidine “
In a few simple steps starting from a commercially available reagents benzyl chloride and potassium thiocyanate, thiocyanate is obtained which is directly reacted with glycine amide to give benzyl thiourea. The used of concentrated HCl give the ring closed product of the latter. The alkylation of 3-benzyl-2- thioxoimidazolidin-4-one is made by the used of methyl iodide under basic condition. Subsequent treatment of the alkyl derivative 3-benzyl-2-(methylthio)-3,5dihydro-4-imidazole with diethyl phosphono cyanate gives the nitrile derivatives which upon treatment with sulphuric acid and functional group manipulations gave 1-benzyl-5-chloromethylimidazolium chloride. This compound is converted mildly under O'Donnell conditions into the l- Histidine derivative. After deprotection L-Histidine is obtained in good yield with 99% enantiomeric excess. This synthetic scheme allows access to any isotopomer of L-histidine and many other biologically important imidazole derivatives.
Autoren-Porträt von Sarra Talab
Talab, SarraAssistant professor Organic chemistry,Chemistry Department, Collage of Science, Al Imam Mohammad Ibn Saud Isalmic University Riyadh Saudi Arabia
Bibliographische Angaben
- Autor: Sarra Talab
- 2018, 120 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 6139984785
- ISBN-13: 9786139984787
Sprache:
Englisch
Kommentar zu "A Novel Synthesis Of Isotopically Labelled L-Histidine"
Schreiben Sie einen Kommentar zu "A Novel Synthesis Of Isotopically Labelled L-Histidine".
Kommentar verfassen