A3 ADENOSINE RECEPTORS FROM CE
(Sprache: Englisch)
This book covers the current state of knowledge of the adenosine A3 receptor. Coverage includes data from studies of theoretical, molecular, and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications.
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This book covers the current state of knowledge of the adenosine A3 receptor. Coverage includes data from studies of theoretical, molecular, and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications.
Klappentext zu „A3 ADENOSINE RECEPTORS FROM CE “
This book, with its 16 chapters, documents the present state of knowledge of the adenosine A receptor. It covers a wide range of information, including data from 3 studies of theoretical, molecular and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications. It fills an important gap in the literature since no alternative source of such information is currently available. Although the A receptor is increasingly being recognized for 3 its increasing number of biological roles throughout the body and many A receptor 3 ligands have proven useful in elucidating peripheral and central pathologies, many issues remain unresolved. Moreover, research activity in this field continues to grow exponentially, resulting in a constant flow of new information. The chapters in this book cover both basic science and the relevant applications and provide an authoritative account of the current status of the field. They have enabled my goal as editor to make "A Adenosine Receptors from Cell Biology to Pharmacology and 3 Therapeutics" an up to date, scientifically excellent, reference source, attractive to basic and clinical scientists alike, a reality. Detailed understanding of the physico-chemical aspects and molecular biology of the A receptor provides a solid basis for its future development as a target for 3 adenosine-based pharmacotherapies (Chapters 2 and 3).
This book, "A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics", documents the present state of knowledge of the adenosine A3 receptor. Adenosine A3 receptors are G protein-linked receptors that function in physiology and intracellular signaling and are involved in inflammatory responses and mediating cell proliferation and cell death.
The A3 receptor is increasingly being recognized for its biological roles throughout the body, and many A3 receptor ligands have proven useful in elucidating peripheral and central pathologies. This book covers a wide range of information including data from studies of theoretical, molecular and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications. The book includes sections on: A3 Adenosine Receptor signal transduction, adenosine Receptor medicinal chemistry, effects and therapeutic applications of Adenosine Receptors on tissues and organs, adenosine Receptors and inflammatory and auto-immune diseases, adenosine Receptors and cancer.
The chapters in this book cover both fundamental science and relevant applications and provide an authoritative account of the current status of the field. "A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics" is an up to date and scientifically excellent source of information, attractive to basic and clinical scientists alike.
The A3 receptor is increasingly being recognized for its biological roles throughout the body, and many A3 receptor ligands have proven useful in elucidating peripheral and central pathologies. This book covers a wide range of information including data from studies of theoretical, molecular and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications. The book includes sections on: A3 Adenosine Receptor signal transduction, adenosine Receptor medicinal chemistry, effects and therapeutic applications of Adenosine Receptors on tissues and organs, adenosine Receptors and inflammatory and auto-immune diseases, adenosine Receptors and cancer.
The chapters in this book cover both fundamental science and relevant applications and provide an authoritative account of the current status of the field. "A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics" is an up to date and scientifically excellent source of information, attractive to basic and clinical scientists alike.
Inhaltsverzeichnis zu „A3 ADENOSINE RECEPTORS FROM CE “
PREFACE.- Pier Andrea Borea.- INTRODUCTION¿.- From hypertension (+) to asthma: interactions with the adenosine A3 receptor from a personal perspective (John Fozard).- SECTION: PHYSICO- CHEMICAL PROPERTIES AND MOLECULAR BIOLOGY.- Thermodynamic analysis in drug-receptor binding: the A3 adenosine receptor (Pier Andrea Borea, Stefania Gessi, Stefania Merighi and Katia Varani).- Pharmacology and molecular biology of A3 adenosine receptors (Karl-Norbert Klotz).- SECTION: SIGNAL TRANSDUCTION.- Regulation of second messenger systems and intracellular pathways (Stefania Merighi, Carolina Simioni, Rob Lane and Adriaan P. IJzerman.- Desensitisation in A3 adenosine receptor regulation: physiopathological implications (M. Letizia Trincavelli, Osele Ciampi and Claudia Martini).- SECTION: MEDICINAL CHEMISTRY.- 6. A3 receptor agonists: history and future perspectives (Kenneth A. Jacobson, Zhan-Guo Gao, Dilip K. Tosh, Gangadhar J. Sanjayan and Sonia de Castro).- 7. A3 adenosine receptor antagonists: history and future perspectives (Pier Giovanni Baraldi, Romeo Romagnoli, Giulia Saponaro, Stefania Baraldi, Mojgan Aghazadeh Tabrizi and Delia Preti).- 8. Molecular modeling and re-engineering of A3 adenosine receptors (Stefano Moro, Erika Morizzo and Kenneth A. Jacobson).- SECTION: EFFECTS ON TISSUES AND ORGANS AND THERAPEUTIC APPLICATIONS.- 9. Adenosine A3 receptor signaling in the central nervous system (Felicita Pedata, Anna Maria Pugliese, Ana M. Sebastião and Joaquim A. Ribeiro).- 10. Cardiovascular biology of the A3 adenosine receptor (John P. Headrick, Jason N. Peart, Tina C. Wan, Wai-Meng Kwok and John A. Auchampach).- 11. A3 adenosine receptor in the pulmonary system (Yifat Klein and Idit Matot).- 12. A3 adenosine receptor regulation of cells of the immune system and modulation of inflammation (Stefania Gessi, Valeria Sacchetto, Eleonora Fogli and JohnFozard).- 13. Adenosine A3 receptors in muscle protection (Bruce T. Liang, Maria Urso, Edward Zambraski and Kenneth A.
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Jacobson).- 14. A3 adenosine receptors, HIF-1 modulation and atherosclerosis (Stefania Gessi, Stephen MacLennan, Edward Leung and Pier Andrea Borea).- SECTION: INFLAMMATORY AND AUTO-IMMUNE DISEASES.- 15. Rheumatoid arthritis: history, molecular mechanisms and therapeutic applications (Pnina Fishman and Sara Bar-Yehuda).- SECTION: CANCER.- 16. Agonists and antagonists: molecular mechanisms and therapeutic applications (Pnina Fishman, Sara Bar-Yehuda, Katia Varani, Stefania Gessi, Stefania Merighi and Pier Andrea Borea).
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Bibliographische Angaben
- 2009, XVI, 322 Seiten, Maße: 16,7 x 24,1 cm, Gebunden, Englisch
- Herausgegeben: Pier Andrea Borea
- Verlag: Springer Netherland
- ISBN-10: 904813143X
- ISBN-13: 9789048131433
Sprache:
Englisch
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