Adherens Junctions: from Molecular Mechanisms
(Sprache: Englisch)
Cell-cell adhesion is fundamental for the development and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the best understood cell-cell adhesion complexes. In this volume, a group of internationally recognized experts reviews AJ...
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Klappentext zu „Adherens Junctions: from Molecular Mechanisms “
Cell-cell adhesion is fundamental for the development and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the best understood cell-cell adhesion complexes. In this volume, a group of internationally recognized experts reviews AJ biology over a wide range of organization; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and overall animal development. AJs have also been an integral part of animal evolution, and play central roles in cancer development, pathogen infection and other diseases. This book addresses major questions encompassing AJ biology. . How did AJs evolve? . How do cadherins and catenins interact to assemble AJs and mediate adhesion? . How do AJs interface with other cellular machinery to couple adhesion with the whole cell? . How do AJs affect cell behaviour and multicellular development? . How can abnormal AJ activity lead to disease?
Inhaltsverzeichnis zu „Adherens Junctions: from Molecular Mechanisms “
1. An introduction to adherens junctions: from molecular mechanisms to tissue development and disease; Tony HarrisPart I: How AJs evolved2. Evolution of the cadherin-catenin complex; Hiroki Oda
Part II: How cadherins and catenins interact to assemble AJs3. The three-dimensional structure of the cadherin-catenin complex; Noboru Ishiyama and Mitsuhiko Ikura4. Biophysics of cadherin adhesion; Deborah Leckband and Sanjeevi Sivasankar5. Adherens junction assembly; Sergey Troyanovski
Part III: How AJs interface with other cellular machinery6. The cytoskeleton and classical cadherin adhesions; Siew Ping Han and Alpha Yap7. Immunoglobulin superfamily receptors and adherens junctions; Yohei Shimono, Yoshiyuki Rikitake, Kenji Mandai, Masahiro Mori and Yoshimi Takai8. Signaling from the adherens junction; Abbye McEwen, David Escobar and Cara Gottardi9. Adherens junction turnover: regulating adhesion through cadherin endocytosis, degradation, and recycling; Benjamin Nanes and Andrew Kowalczyk
Part IV: How AJs affect cell behaviour and multicellular development10. Adherens junctions during cell migration; Sandrine Etienne-Manneville11. Adherens junctions and cadherins in Drosophila development; Annalisa Letizia and Marta Llimargas12. Adherens junctions in C. elegans embryonic morphogenesis; Stephen Armenti and Jeremy Nance13. Cadherin function during Xenopus gastrulation; Rudolf Winklbauer14. Adherens junctions in mammalian development, homeostasis and disease: lessons from mice; Barbara Boggetti and Carien Niessen
Part V: How AJs affect tissue homeostasis and disease15. Adherens junctions and stem cells; Terry Lechler16. Adherens junctions and cancer; Valeri Vasioukhin17. Adherens junctions and pathogens entry; Georgios Nikitas and Pascale Cossart
Index
Bibliographische Angaben
- VI, 431 Seiten, 57 farbige Abbildungen, 5 Schwarz-Weiß-Abbildungen, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben: Tony Harris
- Verlag: Springer Netherland
- ISBN-10: 9400741855
- ISBN-13: 9789400741850
- Erscheinungsdatum: 08.06.2012
Sprache:
Englisch
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