Alpha-Keto Acid Dehydrogenase Complexes

Interaction of protein domains in the assembly and mechanism of 2-oxo acid dehydrogenase multienzyme complexes.- Probing the active site of mammalian pyruvate dehydrogenase.- Role of the E2 core in the dominant mechanisms of regulatory control of mammalian pyruvate dehydrogenase complex.- Lipoamide dehydrogenase.- Plant pyruvate dehydrogenase complexes.- Regulation of the pyruvate dehydrogenase complex during the aerobic/anaerobic transition in the development of the parasitic nematode, Ascaris suum.- Structure, function and assembly of mammalian branched-chain ?-ketoacid dehydrogenase complex.- Lipoylation of E2 component.- Pyruvate dehydrogenase phosphatase.- The mitochondrial ?-ketoacid dehydrogenase kinases: Molecular cloning, tissue-specific expression and primary structure analysis.- Shorter term and longer term regulation of pyruvate dehydrogenase kinases.- Hormonal and nutritional modulation of PDHC activity status.- Regulation of branched-chain ?-keto acid dehydrogenase complex in rat liver and skeletal muscle by exercise and nutrition.- Dephosphorylation of PDH by phosphoprotein phosphatases and its allosteric regulation by inositol glycans.- Long-term regulation and promoter analysis of mammalian pyruvate dehydrogenase complex.- The sperm-specific pyruvate dehydrogenase E1? genes.- Molecular defects of the branched-chain ?-keto acid dehydrogenase complex: maple syrup urine disease due to mutations of the E1? or E1? subunit gene.- Human defects of the pyruvate dehydrogenase complex.- Multigenic basis for maple syrup urine disease with emphasis on mutations in branched chain dihydrolipoyl acyltransferase.- Structure and chromosomal localization of the human 2-oxoglutarate dehydrogenase gene.- Pyruvate dehydrogenase complex as an autoantigen in primarybiliary cirrhosis.