Analysis of Signalling Events
A Method to Integrate Protein Interaction and Gene Expression Data
(Sprache: Englisch)
Signaltransduction is crucial for the interplay of cells in multicellular organisms and controls among other things cellular proliferation and differentiation. The complexity of signalling networks and the absence of comprehensive and accurate quantitative...
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Signaltransduction is crucial for the interplay of cells in multicellular organisms and controls among other things cellular proliferation and differentiation. The complexity of signalling networks and the absence of comprehensive and accurate quantitative data proves a mathematical description difficult. This work deals with the questions, if and how predications about signalling processes for specific cellular models can be made with the aid of interaction databases and gene expression profiles.Starting from molecular interaction-databases complex networks are generated comprising all known cellular signalling paths. But not all of them play a role in a specific cellular model. The specific adaptation of the networks to a given system is achieved by additional integration of gene expression data. The proposed method is able to cope with contradicting data and pays attention to the importance of feedback loops for differentiation processes.The book is primarily intended for an audience interested either in methods to analyse large cyclic networks for which insufficient data is available or to integrate information from genomics and proteomics.
Autoren-Porträt von Dr. Sotirios Ziagos, Sotirios Ziagos
Sotirios Ziagos, Dr.Dr.rer.nat. Sotirios Ziagos: studied physics at Justus-Liebig Universität Gießen and did his doctoral work on modelling of signal transduction networks at Clinical Centre of Friedrich-Schiller Universität Jena and Ruprecht-Karls Universität Heidelberg. At present he is working as a software developer and lives in London.
Bibliographische Angaben
- Autoren: Dr. Sotirios Ziagos , Sotirios Ziagos
- 2008, 104 Seiten, Maße: 15 x 22 cm, Kartoniert (TB), Englisch
- Verlag: VDM Verlag Dr. Müller e.K.
- ISBN-10: 363903046X
- ISBN-13: 9783639030464
Sprache:
Englisch
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