Biomarkers for Alzheimer's Disease Drug Development
(Sprache: Englisch)
This volume aims to build a new generation of experts with a broader understanding of key topics in the Alzheimer's disease field. Chapters guide readers through innovative approaches to the discovery of novel biomarkers in cerebrospinal fluid, innovation...
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This volume aims to build a new generation of experts with a broader understanding of key topics in the Alzheimer's disease field. Chapters guide readers through innovative approaches to the discovery of novel biomarkers in cerebrospinal fluid, innovation in blood-based biomarkers, a comprehensive overview of magnetic resonance imaging and molecular imaging approaches and their value for developing drugs for Alzheimer's disease, cutting-edge developments in neuropathology and their relevance for Alzheimer's disease trials, novel genomic strategies for biomarker development, and related topics including neuropsychological testing and advanced analytical methods.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Biomarkers for Alzheimer's Disease Drug Development aims to ensure successful results in the further study of this vital field.
Inhaltsverzeichnis zu „Biomarkers for Alzheimer's Disease Drug Development “
PART I: The need for Alzheimer's Disease Biomarkers 1. Epidemiology of Dementia: The Burden on Society, the Challenges for Research
Frank J. Wolters and M. Arfan Ikram
2. Population-based Approaches to Alzheimer's Disease Prevention
Robert Perneczky
3. Systems Biology Methods for Alzheimer's Disease Research towards Molecular Signatures, Subtypes and Stages and Precision Medicine. Application in Cohort Studies and Trials
Juan I. Castrillo, Simone Lista, Harald Hampel, and Craig W. Ritchie
PART II: Innovative Approaches to Cerebrospinal Fluid Biomarker Discovery
4. CSF Lipidomics Analysis: High-Resolution Mass Spectrometry Analytical Platform
Paul L. Wood and Randall L. Woltjer
5. CSF N-glycomics using MALDI MS Techniques in Alzheimer's Disease
Angelo Palmigiano, Angela Messina, Rosaria Ornella Bua, Rita Barone, Luisa Sturiale, Mario Zappia, and Domenico Garozzo 6. MicroRNA Profiling of Alzheimer's Disease Cerebrospinal Fluid Johannes Denk and Holger Jahn
Part III: Novel Blood-based Biomarkers
7. Validation of a Chemiluminescence Immunoassay for Measuring Amyloid-ß in Human Blood Plasma
Jonathan Vogelgsang, Jens Wiltfang, and Hans-W. Klafki
8. Mass Spectrometry-based Metabolomic Multiplatform for Alzheimer's Disease Research Raúl González-Domínguez, Álvaro González-Domínguez, Ana Sayago, and Ángeles Fernández-Recamales
9. Blood-based Biomarker Screening with Agnostic Biological Definitions for an Accurate Diagnosis within the Dimensional Spectrum of Neurodegenerative Diseases
Filippo Baldacci, Simone Lista, Sid E. O'Bryant, Roberto Ceravolo, Nicola Toschi, and Harald Hampel,
Part
... mehr
IV: Magnetic Resonance Imaging Methods
10. Functional Magnetic Resonance Imaging in Alzheimer' Disease Drug Development
Stefan Holiga, Ahmed Abdulkadir, Stefan Klöppel, and Juergen Dukart
11. Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies
Carles Falcon, Grégory Operto, José Luis Molinuevo, and Juan Domingo Gispert
12. Hybrid PET-MRI in Alzheimer's Disease Research
Ismini C. Mainta, Maria I. Vargas , Sara Trombella, Giovanni B. Frisoni, Paul G. Unschuld, Valentina Garibotto
Part V: Molecular Imaging Approaches
13. Amyloid PET Imaging: Standardization and Integration with Other Alzheimer Disease Biomarkers Silvia Morbelli and Matteo Bauckneht
14. The use of 18F-FDG PET in the Diagnostic Workup of Alzheimer's Dementia
Marion M. Ortner
15. Quantification of Tau Load in Alzheimer's Disease Clinical Trials Using Positron Emission Tomography Tessa Timmers, Bart N.M. van Berckel, Adriaan Lammertsma, and Rik Ossenkoppele
16. Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach
Elena Rodriguez-Vieitez and Agneta Nordberg
Part VI: Neuropathology
17. Unbiased Lipidomics and Metabolomics of Human Brain Samples
Giuseppe Astarita, Matteo Stocchero, and Giuseppe Paglia
18. Neuropathological Assessment as an Endpoint in Clinical Trial Design
Steve Gentleman and Alan King Lun Liu
Part VII Genomic Methods
19. Analysis of micro-RNA Expression by qPCR on a Microfluidics Platform for Alzheimer's Disease Biomarker Discovery Petros Takousis
20. Telomere length shortening in Alzheimer's disease - procedures for a causal investigation using single nucleotide polymorphisms in a Mendelian Randomization study Yiqiang Zhan, Sara Hägg
21. Quantifying miRNA Deregulation in Alzheimer's Disease
Ana L. Cardoso and Joana R. Guedes
Part VIII: Preclinical Research
22. Imaging of Microglial Activation in Alzheimer's Disease by [11C]PBR28 PET
Cornelius K. Donat, Nazanin Mirzaei, Sac-Pharm Tang, Paul Edison, and Magdalena Sastre
23. In Vivo Two-photon Calcium Imaging of Hippocampal Neurons in Alzheimer Mouse Models
Marc Aurel Busche
Part IX: Related concepts: Cognitive Testing and Advanced Analytics
24. Cognitive Assessment in Alzheimer's Disease Clinical Trials
Geraint Price
25. Data Mining and Machine Learning Methods for Dementia Research
Rui Li
10. Functional Magnetic Resonance Imaging in Alzheimer' Disease Drug Development
Stefan Holiga, Ahmed Abdulkadir, Stefan Klöppel, and Juergen Dukart
11. Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies
Carles Falcon, Grégory Operto, José Luis Molinuevo, and Juan Domingo Gispert
12. Hybrid PET-MRI in Alzheimer's Disease Research
Ismini C. Mainta, Maria I. Vargas , Sara Trombella, Giovanni B. Frisoni, Paul G. Unschuld, Valentina Garibotto
Part V: Molecular Imaging Approaches
13. Amyloid PET Imaging: Standardization and Integration with Other Alzheimer Disease Biomarkers Silvia Morbelli and Matteo Bauckneht
14. The use of 18F-FDG PET in the Diagnostic Workup of Alzheimer's Dementia
Marion M. Ortner
15. Quantification of Tau Load in Alzheimer's Disease Clinical Trials Using Positron Emission Tomography Tessa Timmers, Bart N.M. van Berckel, Adriaan Lammertsma, and Rik Ossenkoppele
16. Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach
Elena Rodriguez-Vieitez and Agneta Nordberg
Part VI: Neuropathology
17. Unbiased Lipidomics and Metabolomics of Human Brain Samples
Giuseppe Astarita, Matteo Stocchero, and Giuseppe Paglia
18. Neuropathological Assessment as an Endpoint in Clinical Trial Design
Steve Gentleman and Alan King Lun Liu
Part VII Genomic Methods
19. Analysis of micro-RNA Expression by qPCR on a Microfluidics Platform for Alzheimer's Disease Biomarker Discovery Petros Takousis
20. Telomere length shortening in Alzheimer's disease - procedures for a causal investigation using single nucleotide polymorphisms in a Mendelian Randomization study Yiqiang Zhan, Sara Hägg
21. Quantifying miRNA Deregulation in Alzheimer's Disease
Ana L. Cardoso and Joana R. Guedes
Part VIII: Preclinical Research
22. Imaging of Microglial Activation in Alzheimer's Disease by [11C]PBR28 PET
Cornelius K. Donat, Nazanin Mirzaei, Sac-Pharm Tang, Paul Edison, and Magdalena Sastre
23. In Vivo Two-photon Calcium Imaging of Hippocampal Neurons in Alzheimer Mouse Models
Marc Aurel Busche
Part IX: Related concepts: Cognitive Testing and Advanced Analytics
24. Cognitive Assessment in Alzheimer's Disease Clinical Trials
Geraint Price
25. Data Mining and Machine Learning Methods for Dementia Research
Rui Li
... weniger
Bibliographische Angaben
- 2018, 1st ed. 2018, XV, 372 Seiten, 45 farbige Abbildungen, Maße: 18,3 x 26 cm, Gebunden, Englisch
- Herausgegeben: Robert Perneczky
- Verlag: Springer, Berlin
- ISBN-10: 1493977032
- ISBN-13: 9781493977031
- Erscheinungsdatum: 07.03.2018
Sprache:
Englisch
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