Central Nervous System Diseases and Inflammation

Section I - Microglia and CNS Disease.

1. Microglia: a CNS-Specific Tissue Macrophage.
- Shweta S. Puntambekar, Jonathan M. Doose, Monica J Carson.

2. Mechanisms of Microglial Activation by Amyloid Precursor Protein and its Proteolytic Fragments.
- S. A. Austin and C. K. Combs.

3. Pericytes.
- Martin Krüger and Ingo Bechmann.

4. Imaging Microglia in the Central Nervous System: Past, Present, and Future.
- Dimitrios Davalos and Katerina Akassoglou.

Section II - Innate Immune Responses within the Brain.

5. Cytokines in CNS inflammation and disease.
- Malú G. Tansey and Tony Wyss-Coray.

6. Arachidonic acid metabolites: Function in neurotoxicity and inflammation in the central nervous system.
- T.J. Montine.

7. Pattern Recognition Receptors in CNS Disease.
- Pamela A. Carpentier, D'Anne S. Duncan, Stephen D. Miller.

8. The Complement System in the CNS: Thinking again.
- Andrea J. Tenner and Karntipa Pisalyaput.

Section III - Chemokines and CNS Disease.

9. Chemokines and autoimmune demyelination.
- Michaela Fux, Jason Millward, and Trevor Owens.

10. Chemokine actions in the CNS: Insights from transgenic models.
- Marcus Müller and Iain L. Campbell.

11. Chemokines and Spinal Cord Injury.
- Maya N. Hatch and Hans S. Keirstead.

12. The Usual Suspects: Chemokines and Microbial Infection of the Central Nervous System.
- Michelle J. Hickey, Linda N. Stiles, Chris S. Schaumburg, and Thomas E. Lane.

Section IV - Antigen Presentation and Immune Responses within the Brain.

13. CNS Dendritic Cells in Inflammation and Disease.
- Samantha L. Bailey and Stephen D. Miller.

14. MHC class I Expression and CD8+ T Cell Function: Towards the Cell Biology of T-APC Interactions in the Infected Brain.
- Cornelia Bergmann and Pedro Lowenstein.

Edited and authored by top names in the field, this book provides a succinct and well organized reference on inflammatory central nervous system disease. It focuses on current areas of investigation within the fields of neuroimmunology, virology, pharmacology, and disease. Sections of the text focus on specific categories of diseases, examining the pharmacological, virological, and immunological effects of and on the disease. Although other books treat this topic, this book s unique organization provides a quick, concise overview of inflammatory CNS disease. The book is intended for researchers, clinicians, and students in immunology, neuroimmunology, virology, microbiology, pharmacology, and medicine.

From the reviews:



"The involvement of the immune system in central nervous system diseases is highlighted in this book, which details important advances in the understanding of certain aspects of neuroinflammation. ... This is clearly appropriate for clinicians and researchers who are interested in neuroinflammation in the central nervous system. It also can be a valuable research guide for students who are interested in learning some basics on this topic. ... It makes worthwhile contributions to this area." (Christine Maria Rohowsky-Kochan, Doody's Review Service, September, 2008)