Chemoprevention of Cancer and DNA Damage by Dietary Factors

INTRODUCTION - HISTORICAL BACKGROUND
GENERAL PRINCIPLES
Molecular Mechanisms of Cancer Formation
Consequences of DNA Damage
The Role of Nutrition in the Etiology of Human Cancer
Mechanisms of Antimutagenesis and Anticarcinogenesis
(Overview)
Induction of DNA Damage and Cancer by Food Components
Interaction of Dietary Factors with Drug Metabolising Enzymes
Regulation of Drug Metabolising and Antioxidant Enzymes
Interaction of Dietary Factors with Cell Signalling and Cell Division
Hormones and Cancer
DNA Methylation
Prevention of Angiogenesis and Metastasis
Role of Oxidants and Antioxidants
EXPERIMENTAL MODELS AND METHODS USED IN CHEMOPREVENTION STUDIES
Experiments Concerning the Prevention of DNA damage
Preneoplastic Foci Models and Long Term Carcinogenicity Studies with Rodents
Methods Used to Study Alterations of Cell Signalling and Proliferation
Measurement of Drug Metabolising Enzymes
Detection of Dietary Antioxidants
Genomics and Proteomics
Design of Epidemiological Studies
SELECTED CHEMOPREVENTIVE DIETARY FACTORS AND COMPONENTS
Carotenoids and Vitamin A
Vitamins D, C, E
Folate and Vitamins B6 and B12
Phytosterins
Saponins (should we include this chapter)
Glucosinolates and Cruciferous Vegetables
Selected Flavonoids
Selected Phenolic Compounds
Sulfides in Allium Vegetables
Chlorphylls
Dietary Fibers
Non Starch Polysaccharides and their Degradation Products
Fatty acids (should we include this chapter)
Coffee and its Constituents
Teas
Green Tea and its Constituents
Chung
Other teas
Protective Components of Alcoholic Beverages
Wine
Beer
Selected Spices and their ingredients
Protease Inhibitors
Phytoestrogens
Lignans in Cereals
Isoflavones in Soy
Lactobacilli and Fermented Foods
Micronutrients (Zinc, Selenium, ect)

Siegfried Knasmüller is head of the Chemoprevention Group at the Institute of Cancer Research. Having obtained his academic degrees from the Vienna University he continued his studies in the fields of genetic toxicology and cancer research at the University of Leiden, Case Western Reserve University, at US EPA in North Carolina and at the Institute of Experimental Cancer Research in Innsbruck before taking up his present appointment at the Medical University of Vienna. Prof. Knasmüller authored over 160 scientific publications and organized several international conferences on cancer chemoprevention and antimutagenesis and is member of the editoral board of a number of scientific journals such as Mutation Research, Mutagenesis and Food and Chemical Toxicology.