Clinical Trials in Neurology

Preface: S.D. Shorvon Introduction: R.J. Guiloff
PART I. GENERAL PRINCIPLES Ethical and Clinical Aspects
Chapter 1. Ethical Considerations
Chapter 2. Assessment Measures and Clinical Scales
Chapter 3. Ethics, Outcome Variables and Clinical Scales: The Clinician's Point of View
Chapter 4. The Cochrane Collaboration Reviews in Neurology Drug Development and Regulation
Chapter 5. Drug Development Stages
Chapter 6. Drug Regulatory Requirements in the United Kingdom and Europe
Chapter 7. Drug Regulatory Requirements in the United States
Chapter 8. Quality Control and Data Monitoring: A Guide to Good Clinical Practice Statistical Aspects
Chapter 9. Statistical Issues in Clinical Trials in Neurology
Chapter 10. Analysis of Results: Statistical Principles
Chapter 11. Survival Analysis
Chapter 12. The Intention-to-Treat Principle for Clinical Trials
Chapter 13. Statistical Analysis of Repeated-Measures Data with Drop-outs
Chapter 14. The Role of Meta-analyses in Clinical Research: Uses and Limitations
Part II. DISEASE APPLICATIONS Dementia
Chapter 15. Outcome Variables in Dementia Trials: Conceptual and Practical Issues
Chapter 16: Dementia: Experience with Large Multicentre Trials Cerebrovascular disease
Chapter 17: Cerebrovascular Disease: Basic Designs, Sample Sizes and Clinical Scales
Chapter 18: Clinical Trials in Stroke Prevention in North America
Chapter 19: Cerebrovascular Disease: Experience with Large Multicentre Trials Epilepsy
Chapter 20: Epilepsy: Ethics, Outcome Variables and Clinical Scales
Chapter 21: Epilepsy: Basic Designs, Sample Sizes and Experience with Large Multicentre Trials Headache
Chapter 22: Headache: Ethics, Outcome Variables and Clinical Studies
Chapter 23: Headache: BasicDesigns, Sample Size and Pitfalls
Chapter 24: Headache: Experience with Large Multicentre Trials in the Treatment of Migraine Attacks Extrapyramidal disease
Chapter 25: Parkinson's Disease: Ethics, Outcome Variables and

"This much needed book is a gem.  If you are involved in a clinical trial make sure you and all your collaborators have read it, before the trial commences...This book provides the information the clinician needs to understand how trials are organised, how data are collected, how they are analysed, and how their clinical significance should be assessed.  Dr Guiloff has assembled an impressive team of contributors, all with expertise and experience in their subject.

"The consistent high quality of [the] chapters is remarkable in a multiauthored text and a tribute to the hard work of the editor.  The book concludes with a review by Michael Brooke that should be required reading for every neurologist.  This book not only fills a gap on the neurologist's bookshelf but also will be opened again and again"

-Michael Swash