Computational Drug Designing of MraY in Pathogenic Atherosclerosis
(Sprache: Englisch)
Atherosclerosis is a multifactorial vascular inflammatory disease which is one of top most common cause of deaths around worldwide. Implementing Bioinformatics tools, phospho-MurNAc-pentapeptide translocase (MraY) was identified as one of the crucial drug...
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Atherosclerosis is a multifactorial vascular inflammatory disease which is one of top most common cause of deaths around worldwide. Implementing Bioinformatics tools, phospho-MurNAc-pentapeptide translocase (MraY) was identified as one of the crucial drug targets against eleven pathogens causing atherosclerosis. MraY is an essential enzyme membrane which plays a crucial role in catalyzing the essential step of bacterial cell wall biosynthesis in Gram-negative bacteria. The enzyme MraY mainly involves in the peptidoglycan biosynthesis which is unique and important for the survival of pathogens. Therefore, by blocking MraY function with lead 1 would dissolve the structural integrity, flexibility and rigidity of the cell wall and expose the pathogens to osmotic lysis and hinders the proliferation of eleven pathogens causing atherosclerosis. Hence, lead 1 will provide a framework for developing new antagonists against the eleven pathogens causing atherosclerosis.
Autoren-Porträt von Kanipakam Hema
Hema, KanipakamMSc (Gold Medalist) & PhD Bioinformatics, at Sri Venkateswara Institute of Medical Sciences (SVIMS) Tirupati, worked as DBT Trainee, DST-INSPIRE Jr & Sr Research Fellow with 51 Research papers/abstracts published in national and international journals/conferences. Awarded with 8 Best Paper/Poster. Presently working as Scientist at ICGEB, Delhi.
Bibliographische Angaben
- Autor: Kanipakam Hema
- 2019, 56 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 6200214239
- ISBN-13: 9786200214232
Sprache:
Englisch
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