Diabetes - Perspectives in Drug Therapy

Preface. Targeting type 2 diabetes. Dual acting and pan-PPAR activators as potential anti-diabetic therapies. GLP-agonists and Dipeptidyl-Peptidase IV Inhibitors. Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes. SGLT Inhibitors as New Therapeutic Tools in the Treatment of Diabetes. Inhibitors of 11b-hydroxysteroid dehydrogenase type 1 in antidiabetic therapy. Nampt and its potential role in inflammation and type 2 diabetes. Inhibition of ganglioside biosynthesis as a novel therapeutic approach in insulin resistance. Overcoming Insulin Resistance with Ciliary Neurotrophic Factor. Thermogenesis and related metabolic targets in anti-diabetic therapy. Interleukin targeted therapy for metabolic syndrome and type 2 diabetes. Fructose-1, 6-Bisphosphatase Inhibitors for Reducing Excessive Endogenous Glucose Production in Type 2 Diabetes. AMP-activated protein kinase and metabolic control. Mitochondria as potential targets in antidiabetic therapy. Research and development of glucokinase activators for diabetes therapy: theoretical and practical aspects