Endothelial Cell Biology in Health and Disease
(Sprache: Englisch)
Although blood capillaries were first observed through a flea-lens microscope by Malpighi in 1661,200 more years elapsed before the cellular nature of the vessel wall was conclusively demonstrated. Beginning with the middle of the 19th cen tury, our...
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Klappentext zu „Endothelial Cell Biology in Health and Disease “
Although blood capillaries were first observed through a flea-lens microscope by Malpighi in 1661,200 more years elapsed before the cellular nature of the vessel wall was conclusively demonstrated. Beginning with the middle of the 19th cen tury, our knowledge of the histological organization of blood vessels has steadily increased. However, the endothelium, which for a long time was considered to be just an inert barrier lining, had been barely explored until three decades ago. Since then, there has been an upsurge of interest in the fine structure and function of endothelial cells. Intense in vivo and in vitro investigations have revealed that the endothelial cell is a key element in a wide variety of normal activities and diseases. A large number of investigators and laboratories have been attracted to endothelial cell research, thus supporting the expansion of the continuously grow ing and diversifying field of endotheliology. The number of articles published annually on this subject has increased from a few score at the beginning of the 1970s to more than a thousand in recent years, and an increasing number of journals, books, societies, and symposia focused primarily on the vascular en dothelium have marked the last decade.
Inhaltsverzeichnis zu „Endothelial Cell Biology in Health and Disease “
I. Structure-Function Correlations in Endothelial Cells1. The Microvascular Endothelium Revisited
I. Well-Established Knowledge
II. New Information
III. Controversies
IV. New Developments
V. Concluding Remarks
- References
2. Ultrastructural Studies of Capillary Endothelium: Compartmental Tracing, High-Voltage Electron Microscopy, afid Cryofixation
I. Introduction
II. Three-Dimensional Analysis of the Capillary Wall
III. Fixation of Capillary Endothelium for Electron Microscopy
IV. Structure-Function Relationships in the Capillary Wall
V. Concluding Remarks
- References
II. Transport Functions of Endothelial Cells
3. Transport Pathways and Processes
I. Introduction
II. The "Pore" Theory of Capillary Permeability
III. Morphologically Identified Transport Pathways
IV. A Pathophysiological Transport Pathway
V. Relation of Endothelial Structure to Its Transport Function
VI. Concluding Remarks
- References
4. Receptor-Mediated Trariscytosis of Plasma Molecules by Vascular Endothelium
I. Introduction
II. Endothelial Cell Regulation of Vascular Permeability
III. Molecular Interactions at Plasma-Endothelial Interface
IV. Sorting of Molecules: Endocytosis and Transcytosis
V. Receptor-Mediated Transcytosis
VI. Endothelial Cells of Continuous Capillaries Express Albumin Binding Proteins
- Receptor-Mediated Transcytosis Is a Basic Process Shared by Most Epithelia
- Concluding Remarks
- References
5. Studies of Pulmonary Endothelial Permeability Using Tritiated Dextrans
I. Introduction
II. Experimental Methods
III. Results
IV. Discussion
V. Concluding Remarks
- References
III. Endothelial Cell Growth and Differentiation
6. Endothelial Morphogenesis
I. Developmental Biology of the Endothelium
II. Endothelial Replication in Vivo
III. Inhibition of Endothelial Replication by Cell-Cell Interaction
IV. Cell-Cell and Cell-Substrate Adhesion Molecules
V. Morphogenic Control of Growth: A Hypothesis
- References
IV.
... mehr
Endothelial Cytoskeleton and Matrix and Their Interactions
7. The Endothelial Junction: The Plaque and Its Components
I. Introduction
II. Electron Microscopy of Endothelial Junctions
III. Characterization of Junctions by Marker Proteins
IV. Immunolocalization of Cytoskeletal Proteins in Endothelial Cells
V. Structure-Bound and Soluble Forms of Junction Plaque Proteins
VI. The Endothelial Junction as a Zonula Adhaerens: Conclusions and Perspectives
- References
8. Endothelial Cell-Extracellular Matrix Interactions: Matrix as a Modulator of Cell Function
I. Introduction
II. Endothelial Cell-Subendothelial Matrix Interactions: In Vivo Considerations
III.Endothelial Cell-Extracellular Matrix Interactions: In Vitro Considerations
IV. Concluding Remarks
- References
V. Endothelial Cell Anticoagulant and Fibrinolytic Activities
9. Assembly and Function of the Protein C Anticoagulant Pathway on Endothelium
I. Introduction
II. Protein C-Structural Domains
III. Expression of Protein C-Anticoagulant Activity
IV. Discovery of TM
V. Comparison of Purified TM with the Endothelial Cell Surface
VI. Influence of TM on Thrombin Specificity
VII. Variation of TM Properties between Cell Lines
VIII. Expression of Activated Protein C Anticoagulant Activity
IX. Regulation of Endothelial Cell TM Activity during Inflammatory Responses
X. Review of the Protein C System in Thrombotic Disease
XI. Perspectives
XII. Concluding Remarks
- References
10. The Biochemistry and Physiology of Anticoagulantly Active Heparinlike Molecules
I. Introduction
II. Heparin-Antithrombin Interaction
III. Structure-Function Relationship between Heparin and Antithrombin
IV. Vascular Tissue Heparan Sulfate
V. Heparan Sulfate Proteoglycans from Endothelial Cells
VI. Physiological Role of Proteoheparan Sulfate
- References
11. The Fibrinolytic System of Cultured Endothelial Cells
I. Introduction
II. Fibrinolytic System of Cultured Endothelial Cells
III. Discussion
- References
VI. Endothelial Cell Procoagulant Activity
12. Vascular Endothelium: Functional Modulation at the Blood Interface
I. Introduction
II. Experimental Procedures
III. Results and Discussion
IV. Perspectives
V. Concluding Remarks
- References
13. Endothelium and the Regulation of Coagulation
I. Introduction
II. A Procoagulant Pathway on the Endothelial Cell Surface
III.Consequences of the Generation of Procoagulant Enzymes in Close Proximity to the Endothelial Cell Surface
IV. Integration of the Endothelial Cell Procoagulant Pathway and Anticoagulant Mechanisms
V. Concluding Remarks
- References
VII. Endothelial Cell Response to Stress Factors
14. Heat-Shock Response as a Possible Model for (Patho)physiological Stress in Endothelial Cells
I. Introduction
II. Materials and Methods
III. Results and Discussion
IV. Perspectives
- References
15. Endothelial Activation: Its Role in Inflammatory and Immune Reactions
I. Actions of Specific Cytokines on Endothelial Cells in Culture
II. . Endothelial Activation in Vivo
- References
16. Intimal Responses to Shear Stress, Hypercholesterolemia, and Hypertension: Studies in the Rat Aorta
I. . The Rat Aorta as an Experimental System
II. Intimal Changes Related to Flow Disturbances: Effects of Acute and Chronic Stenosis
III. Intimal Changes in Hypercholesterolemia: The "Inflammatory Theory" of Atherosclerosis
IV. Shear Stress and Lipid Deposition: A Study Based on Aortic Stenosis
V. Intimal Changes in Hypertension
VI. Perspectives
- References
VIII. Endothelial Cell in Atherogenesis
17. Endothelial Injury and Atherosclerosis
I. Introduction
II. Response to Injury Hypothesis of Atherosclerosis
III. Cellular Interactions during Hypercholesterolemia
IV. Blood Cells, Arterial Cells, and Growth Factor Formation
V. Concluding Remarks
- References
18. Prelesional Changes of Arterial Endothelium in Hyperlipoproteinemic Atherogenesis
I. Introduction
II. Modeling of Experimental Hypercholesterolemia
III. Lesional Stages Considered
IV. Transport of Lipoproteins by the Normal Artery Wall
V. Transport and Accumulation of (3-VLDL in the Artery Wall of Hypercholesterolemic Rabbits
VI. Extracellular Accumulation of Lipoprotein-Derived Components
VII. Changes in the Surface Charge and Chemistry of Arterial Endothelium and Monocytes
VIII. Endothelial Modifications in the Early Stages of Atherogenesis
IX. Concluding Remarks
- References
19. Response of Blood Vessel Cells to Viral Infection
I. Introduction
II. Experimental Procedures
III. Results
IV. Discussion
- References
7. The Endothelial Junction: The Plaque and Its Components
I. Introduction
II. Electron Microscopy of Endothelial Junctions
III. Characterization of Junctions by Marker Proteins
IV. Immunolocalization of Cytoskeletal Proteins in Endothelial Cells
V. Structure-Bound and Soluble Forms of Junction Plaque Proteins
VI. The Endothelial Junction as a Zonula Adhaerens: Conclusions and Perspectives
- References
8. Endothelial Cell-Extracellular Matrix Interactions: Matrix as a Modulator of Cell Function
I. Introduction
II. Endothelial Cell-Subendothelial Matrix Interactions: In Vivo Considerations
III.Endothelial Cell-Extracellular Matrix Interactions: In Vitro Considerations
IV. Concluding Remarks
- References
V. Endothelial Cell Anticoagulant and Fibrinolytic Activities
9. Assembly and Function of the Protein C Anticoagulant Pathway on Endothelium
I. Introduction
II. Protein C-Structural Domains
III. Expression of Protein C-Anticoagulant Activity
IV. Discovery of TM
V. Comparison of Purified TM with the Endothelial Cell Surface
VI. Influence of TM on Thrombin Specificity
VII. Variation of TM Properties between Cell Lines
VIII. Expression of Activated Protein C Anticoagulant Activity
IX. Regulation of Endothelial Cell TM Activity during Inflammatory Responses
X. Review of the Protein C System in Thrombotic Disease
XI. Perspectives
XII. Concluding Remarks
- References
10. The Biochemistry and Physiology of Anticoagulantly Active Heparinlike Molecules
I. Introduction
II. Heparin-Antithrombin Interaction
III. Structure-Function Relationship between Heparin and Antithrombin
IV. Vascular Tissue Heparan Sulfate
V. Heparan Sulfate Proteoglycans from Endothelial Cells
VI. Physiological Role of Proteoheparan Sulfate
- References
11. The Fibrinolytic System of Cultured Endothelial Cells
I. Introduction
II. Fibrinolytic System of Cultured Endothelial Cells
III. Discussion
- References
VI. Endothelial Cell Procoagulant Activity
12. Vascular Endothelium: Functional Modulation at the Blood Interface
I. Introduction
II. Experimental Procedures
III. Results and Discussion
IV. Perspectives
V. Concluding Remarks
- References
13. Endothelium and the Regulation of Coagulation
I. Introduction
II. A Procoagulant Pathway on the Endothelial Cell Surface
III.Consequences of the Generation of Procoagulant Enzymes in Close Proximity to the Endothelial Cell Surface
IV. Integration of the Endothelial Cell Procoagulant Pathway and Anticoagulant Mechanisms
V. Concluding Remarks
- References
VII. Endothelial Cell Response to Stress Factors
14. Heat-Shock Response as a Possible Model for (Patho)physiological Stress in Endothelial Cells
I. Introduction
II. Materials and Methods
III. Results and Discussion
IV. Perspectives
- References
15. Endothelial Activation: Its Role in Inflammatory and Immune Reactions
I. Actions of Specific Cytokines on Endothelial Cells in Culture
II. . Endothelial Activation in Vivo
- References
16. Intimal Responses to Shear Stress, Hypercholesterolemia, and Hypertension: Studies in the Rat Aorta
I. . The Rat Aorta as an Experimental System
II. Intimal Changes Related to Flow Disturbances: Effects of Acute and Chronic Stenosis
III. Intimal Changes in Hypercholesterolemia: The "Inflammatory Theory" of Atherosclerosis
IV. Shear Stress and Lipid Deposition: A Study Based on Aortic Stenosis
V. Intimal Changes in Hypertension
VI. Perspectives
- References
VIII. Endothelial Cell in Atherogenesis
17. Endothelial Injury and Atherosclerosis
I. Introduction
II. Response to Injury Hypothesis of Atherosclerosis
III. Cellular Interactions during Hypercholesterolemia
IV. Blood Cells, Arterial Cells, and Growth Factor Formation
V. Concluding Remarks
- References
18. Prelesional Changes of Arterial Endothelium in Hyperlipoproteinemic Atherogenesis
I. Introduction
II. Modeling of Experimental Hypercholesterolemia
III. Lesional Stages Considered
IV. Transport of Lipoproteins by the Normal Artery Wall
V. Transport and Accumulation of (3-VLDL in the Artery Wall of Hypercholesterolemic Rabbits
VI. Extracellular Accumulation of Lipoprotein-Derived Components
VII. Changes in the Surface Charge and Chemistry of Arterial Endothelium and Monocytes
VIII. Endothelial Modifications in the Early Stages of Atherogenesis
IX. Concluding Remarks
- References
19. Response of Blood Vessel Cells to Viral Infection
I. Introduction
II. Experimental Procedures
III. Results
IV. Discussion
- References
... weniger
Bibliographische Angaben
- 2011, Softcover reprint of the original 1st ed. 1988, 478 Seiten, Maße: 17 x 24,4 cm, Kartoniert (TB), Englisch
- Herausgegeben: M. Simionescu, N. Simionescu
- Verlag: Springer, Berlin
- ISBN-10: 1461282543
- ISBN-13: 9781461282549
Sprache:
Englisch
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