Gadd45 Stress Sensor Genes
(Sprache: Englisch)
This book presents a comprehensive picture of the unique global role Gadd45 genes play as stress sensors and the molecular pathways involved.
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This book presents a comprehensive picture of the unique global role Gadd45 genes play as stress sensors and the molecular pathways involved.
Klappentext zu „Gadd45 Stress Sensor Genes “
Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins). These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity. Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress. Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus. Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.
Inhaltsverzeichnis zu „Gadd45 Stress Sensor Genes “
Gadd45 in stress signaling, cell cycle control and apoptosis.- Gadd45 in Modulation of Solid Tumors and Leukemia.- Gadd45 Proteins: Key players of repair-mediated DNA demethylation.- Gadd45 proteins in Immunity.- Gadd45 in the liver - Signal transduction and transcriptional mechanisms.- The Role of the Gadd45 Family in the Nervous System: A focus on Neurodevelopment, Neuronal Injury, and Cognitive Neuroepigenetics.- Gadd45 stress sensors in preeclampsia.- Index.Bibliographische Angaben
- 2016, Softcover reprint of the original 1st ed. 2013, X, 134 Seiten, 11 farbige Abbildungen, Maße: 15,5 x 23,5 cm, Kartoniert (TB), Englisch
- Herausgegeben: Dan A. Liebermann, Barbara Hoffman
- Verlag: Springer, Berlin
- ISBN-10: 1493953907
- ISBN-13: 9781493953905
Sprache:
Englisch
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