Hedgehog signaling activation in human cancer and its clinical implications
(Sprache: Englisch)
Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics in humans. This volume provides insightful views suitable for clinical scientists, and graduate and undergraduate students alike.
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Produktinformationen zu „Hedgehog signaling activation in human cancer and its clinical implications “
Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics in humans. This volume provides insightful views suitable for clinical scientists, and graduate and undergraduate students alike.
Klappentext zu „Hedgehog signaling activation in human cancer and its clinical implications “
Despite significant progress in our understanding of cancer biology, cancer continues to be the second cause of human mortality. The remarkable responses of cancer patients to inhibitors to the hedgehog signaling pathway implies a promising novel approach to treat cancer. As a result, understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway, initially discovered by two Nobel laureates Drs. E. Wieschaus and C. Nusslein-Volhard in Drosophila, is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that activation of this pathway occurs in a variety of human cancer, including basal cell carcinomas (BCCs), medulloblastomas, leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. Even more exciting is the discovery and synthesis of specific signaling antagonists for the hedgehog pathway, which have significant clinical implications in novel cancer therapeutics. To provide the most up-to-date information on recent development in this exciting research area, we have invited experts in hedgehog signaling field to summarize major advances made in the last few years on hedgehog signaling mechanisms, activation of the pathway in various human cancer types, potential antagonists for hedgehog signaling inhibition and their clinical implications for human cancer treatment. Authors of the book have also highlighted current challenges in our efforts to translate the basic biology into clinic. This book provides insightful views suitable for graduate students, medical students, undergraduate students, basic and clinical scientists, cancer patients as well as the general public.
Despite significant progress in our understanding of cancer biology, cancer continues to be the second cause of human mortality. The remarkable responses of cancer patients to inhibitors to the hedgehog signaling pathway implies a promising novel approach to treat cancer. As a result, understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway, initially discovered by two Nobel laureates Drs. E. Wieschaus and C. Nusslein-Volhard in Drosophila, is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that activation of this pathway occurs in a variety of human cancer, including basal cell carcinomas (BCCs), medulloblastomas, leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. Even more exciting is the discovery and synthesis of specific signaling antagonists for the hedgehog pathway, which have significant clinical implications in novel cancer therapeutics. To provide the most up-to-date information on recent development in this exciting research area, we have invited experts in hedgehog signaling field to summarize major advances made in the last few years on hedgehog signaling mechanisms, activation of the pathway in various human cancer types, potential antagonists for hedgehog signaling inhibition and their clinical implications for human cancer treatment. Authors of the book have also highlighted current challenges in our efforts to translate the basic biology into clinic. This book provides insightful views suitable for graduate students, medical students, undergraduate students, basic and clinical scientists, cancer patients as well as the general public. basal cell carcinomas (BCCs), medulloblastomas, leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. Even more exciting is the discovery and synthesis of specific signaling antagonists for the hedgehog pathway, which have significant clinical implications in novel cancer t
Inhaltsverzeichnis zu „Hedgehog signaling activation in human cancer and its clinical implications “
Chapter 1- Overview of hedgehog signaling pathwayChi-chung Hui and Jin Jiang
Chapter 2- Regulation of Hh morphogene gradient
G. D'Angelo, F. Wendler, K. Ayers and P.P. Thérond
Chapter 3- Smoothened Signaling through a G-protein Effector Network
David J. Robbins and Stacey K. Ogden
Chapter 4- Kinases and phosphatases in hedgehog signaling
Jianhang Jia
Chapter 5- Signaling Cross-talk of Oncogenic KRAS and Hedgehog Pathways in Pancreatic Cancer
Xiaodong Cheng
Chapter 6- Crosstalks between PKC and hedgehog signaling
Jing Li and Mark Evers
Chapter 7- Activation of Hh signaling in human cancer
Jingwu Xie and Ervin Epstein
Chapter 8- Hedgehog signaling in pediatric brain tumors
Joon Won Yoon, Ph.D., Jason Fangusaro, M.D., Philip Iannaccone, M.D., Ph.D., and David Walterhouse, M.D.
Chapter 9- Hedgehog Signaling in Mammary Gland Development and Breast Cancer
Adriana P. Visbal and Michael T. Lewis
Chapter 10- Hedgehog signaling and cancer therapeutic resistance
K.S. Clifford Chao and Yu-Jen Chen
Chapter 11- Small-molecule Inhibitors of the Hedgehog Pathway
Ari J. Firestone and James K. Chen
Chapter 12- Cyclopamine and its derivatives for cancer therapeutics
Martin Tremblay and Karen McGovern
Bibliographische Angaben
- 2011, IX, 217 Seiten, Maße: 15,5 x 23,5 cm, Gebunden, Englisch
- Herausgegeben: Jingwu Xie
- Verlag: Springer, Berlin
- ISBN-10: 1441984348
- ISBN-13: 9781441984340
Sprache:
Englisch
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