Insulin Resistance

Epidemiology.- The Metabolic Syndrome: Definitions, Controversies and Clinical Utility.- Epidemiology of the Metabolic Syndrome and Related Disorders in Children and Adolescents.- Metabolic Syndrome in Children and Adolescents Worldwide.- Maternal-Fetal Contributors to the Insulin Resistance Syndrome in Youth.- Early Childhood Contributions to Insulin Resistance.- Pathophysiology.- Molecular Mechanisms of Insulin Resistance.- Techniques Used to Assess Insulin Action.- Adiposity is The Enemy: Body Composition and Insulin Sensitivity.- Ectopic Fat Deposition, Adiponectin and Insulin Resistance in Obese Adolescents.- Mediators of Insulin Resistance.- Insulin Resistance and the Pathogenesis of Cardiovascular Disease.- Insulin Resistance and Cardiovascular Disease.- The Liver and Insulin Resistance: The Important Convergence of Endocrinology and Hepatology.- Polycystic Ovary Syndrome and Metabolic Syndrome.- Treatment.- Effects of Exercise in Metabolic Syndrome and Diabetes: A Central Role for Insulin Sensitivity.- Weight Loss Medications and the Metabolic Syndrome.

Over the last few years, the understanding of metabolic syndrome has advanced in a number of directions. This book provides an update on the current status of the understanding of insulin resistance and metabolic syndrome in children and adults. There is particular focus on childhood precursors of the disorder (fetal, perinatal, and childhood factors) since this is an area of great promise for prevention of future expansion of the epidemic. The book is divided into three major sections - epidemiology, pathophysiology, and intervention (both pharmacologic and lifestyle) in both adults and children.

From the reviews:

"The editors have gathered world experts in this recently recognized problem in children as well as in the adult disease. Molecular mechanisms and disturbances in physiologic functioning are well covered and need appreciation by comprehensive therapists. Contributors to this book make this learning seem to be easy." (William H Wehrmacher, Comprehensive Therapy, December, 2008)

"Editors Philip Zeitler and Kristen Nadeau have assembled a comprehensive and insightful textbook on the timely topic of insulin resistance and the pediatric antecedents of insulin resistance that lead to adult diseases such as diabetes and cardiovascular disease. ... Many chapters include excellent tables and figures. ... overall, the book is worth the investment in time and money for those with either research or clinical interests in this area." (Lori Laffel, The New England Journal of Medicine, Vol. 360 (20), May, 2009)

"This volume is part of the Series Contemporary Endocrinology. ... The book has 3 parts. ... Clearly written, it is recommended to pediatric endocrinologists and nutritionists." (Pediatric Endocrinology Reviews, Vol. 7 (4), June, 2010)

"Insulin Resistance: Childhood Precursors and Adult Disease, edited by Philip S. Zeitler and Kristen J. Nadeau, provides a timely and comprehensive overview of insulin resistance in children, and the clustering of associated metabolic and cardiovascular risk factors known as the metabolic syndrome. ... this book would be a useful resource for any primary care physician or pediatric subspecialist. ... a helpful resource for any physician seeking to expand his or her understanding of current concepts of insulin resistance and related co-morbid conditions in childhood." (Stavra A. Xanthakos, Practical Gastroenterology, April, 2009)

From the reviews:

"The editors have gathered world experts in this recently recognized problem in children as well as in the adult disease. Molecular mechanisms and disturbances in physiologic functioning are well covered and need appreciation by comprehensive therapists. Contributors to this book make this learning seem to be easy." (William H Wehrmacher, Comprehensive Therapy, December, 2008)

"Editors Philip Zeitler and Kristen Nadeau have assembled a comprehensive and insightful textbook on the timely topic of insulin resistance and the pediatric antecedents of insulin resistance that lead to adult diseases such as diabetes and cardiovascular disease. ... Many chapters include excellent tables and figures. ... overall, the book is worth the investment in time and money for those with either research or clinical interests in this area." (Lori Laffel, The New England Journal of Medicine, Vol. 360 (20), May, 2009)

"This volume is part of the Series Contemporary Endocrinology. ... The book has 3 parts. ... Clearly written, it is recommended to pediatric endocrinologists and nutritionists." (Pediatric Endocrinology Reviews, Vol. 7 (4), June, 2010)

"Insulin Resistance: Childhood Precursors and Adult Disease, edited by Philip S. Zeitler and Kristen J. Nadeau, provides a timely and comprehensive overview of insulin resistance in children, and the clustering of associated metabolic and cardiovascular risk factors known as the metabolic syndrome. ... this book would be a useful resource for any primary care physician or pediatric subspecialist. ... a helpful resource for any physician seeking to expand his or her understanding of current concepts of insulin resistance and related co-morbid conditions in childhood." (Stavra A. Xanthakos, Practical Gastroenterology, April, 2009)