Intensive Care Medicine

'Epithelial-Endothelial Alterations.- Role of Epithelial ICAM-1 in Endotoxin-Induced Lung Injury.- Pulmonary Endothelium-Bound Enzymes in the Normal and the Diseased Lung.- Endothelial Cell Replacement Therapy in the Critically Ill.- Sepsis: Mechanisms and Therapy.- Reconciling Clinical Criteria and the Use of Genetically Engineered Animals in Sepsis Research.- Human Genetics and Human Sepsis: Is the Tail Wagging the Dog?.- Microarray Technology in Sepsis: Tool or Toy.- Update on Anti-Endotoxin Therapies.- An Update of Childhood Meningococcal Sepsis.- The Effect of Alcohol Consumption on Risk of Sepsis and ARDS.- Supplementing Arginine during Sepsis: from Theory to Clinical Practice.- Coagulation Abnormalities.- Severe Thrombotic Microangiopathy in Critically Ill Patients.- Heparin in the Treatment of Critically Ill Patients on the ICU Patients.- Endogenous Anticoagulants and the Role of Heparin in the Treatment of Severe Sepsis.- Is Recombinant Activated Factor VII a Universal Hemostatic?.- Infectious Challenges.- Nasal Carriage of Staphylococcus aureus: Associated Risks and Preventive Measures.- Current Dilemmas in the Management of Adults with Severe Community-Acquired Pneumonia.- Evaluation of Non-Resolving and Progressive Pneumonia.- Candida in Lung Specimens from Non-Neutropenic ICU Patients: Infection or Colonization?.- A Reappraisal of Selective Decontamination of the Digestive Tract.- Management of Catheter-Related Sepsis in the ICU.- Empiric Antibiotics in Critical Illness: Do they Help or Harm?.- Acute Respiratory Failure.- Mortality Rates in Patients with ARDS: What Should be the Reference Standard?.- Sigh in Acute Respiratory Failure.- Ventilatory Support.- The Conditioning of Medical Gases during Spontaneous Breathing.- Recent Innovations in Mechanical Ventilatory Support.- Expiratory Flow Limitation in Mechanically Ventilated Patients.- Respiratory Muscle Unloading during Mechanical Ventilation.- High Frequency Oscillation (HFO): Physiological Basis