Management of Prostate Cancer

Epidemiology of prostate cancer in Europe.- Chemoprevention.- Individual and mass screening.- Anatomo-pathology.- Biology.- Genomics.- Radiologic investigations( multiparametric MRI, whole body MRI).- Nuclear Medecine: follow-up (Choline PET-CT, Radium 223)and treatment of bone metastases.- Diagnosis, clinical work up, TNM classification Markers.- Active surveillance.- Open Radical Prostatectomy.- The robotic laparoscopic radical prostatectomy.- Brachytherapy (Low dose rate).- Brachytherapy (High dose rate).- IMRT, hypofractionated irradiation and stereotactic irradiation.- External irradiation + androgen suppression.- Post-operative irradiation: immediate or early delayed?- High Intensity Focused Ultrasound.- Cryotherapy.- Follow-up after radical treatments* and relapse.- First line hormonal manipulations.- Upfront chemotherapy at initiation of hormonal treatment for metastatic prostate cancer.- Bone-targeted therapies (Bisphosphonates, denosumab and Radium 223.- Targeted therapies and vaccination.- How to interprete results.- Prostate EAU guidelines.- Better Patients perspective.

Michel Bolla M.D. is Professor for Radiation Oncology and Oncology. He received his medical degree at the Joseph Fourier University of Grenoble and had his radiation therapy training at the University Hospital of Grenoble and the Comprehensive Cancer Centre Georges François Leclerc in Dijon. He was appointed Professor in 1986 and was particularly involved in the structuring of Oncology at the Grenoble University Hospital: Head of the Radiation Oncology Department (1997-2009), President of the Federation of Oncology (2000-7), President of the Arc Alpin Oncology Network (2002 -2009). Professor Bolla was nominated as President of the French Society of Radiation Oncology (2006-7): he was particularly involved in the definition of radiotherapy quality criteria (Plan Cancer I) and served as project-manager of the French Radiation Therapy Observatory, under the French National cancer Institute and the French Society of Radiation Oncology umbrella. After serving as Secretary of the Radiation Oncology Group of the European Organization on Research and Treatment of Cancer (EORTC) since 1991, Professor Bolla was elected chairman of the Radiation Oncology Group (1997-2000) then member of the EORTC Board (2000-2006). The focus of his clinical research for many years is prostate cancer: indications of adjuvant radiotherapy after radical prostatectomy, combination of androgen deprivation with external irradiation for locally advanced prostate cancer, which earned him several publications on the New England Journal of Medecine and the Lancet. In 2009 the steering Committee of the 2ND European Multidisciplinary Meeting on Urological Cancers (EAU,ESMO, ESTRO) honoured him as recepient of an award for Excellence in Radiation Oncology.As regard screening, he was one of the promoters of breast, cervix and colon and rectal cancers mass screening for women (50-74 years) in Isère (1990) and he is now trying to implement prostate cancer screening in men.

"Editors M. Bolla and H. Van Poppel with the help of about 50 worldwide experts aimed to revise the first edition of this textbook and present an exhaustive review intended for practitioners involved in prostate cancer management. ... This outstanding textbook offers useful information for urologists and oncologists who are looking for updates on prostate cancer." (European Urology Today, March/May, 2017)