Methionine Dependence of Cancer and Aging

Methods to Study the Role of Methionine Restricted Diet and Methioninase in Cancer Growth Control.- Altered Methionine Metabolism in Cancer Cells.- Linkage of Methionine-Dependence and Other Features of Malignancy.- Isolation and Characterization of Methionine Independent Clones from Methionine Dependent Cancer Cells.- Tumor-Specific S/G2-Phase Cell Cycle Arrest of Cancer Cells by Methionine Restriction.- Preclinical Breast Cancer Models to Investigate Metabolic Priming by Methionine Restriction.- Efficacy of Methionine-Restricted Diets on Cancers In Vivo.- Dietary Methionine-Restriction Based Cancer Chemotherapy in Rodents.- Clinical Studies of Methionine-Restricted Diets for Cancer Patients.- Development of Recombinant Methioninase for Cancer Treatment.- Methioninase Cell-Cycle Trap Cancer Chemotherapy.- High Efficacy of Recombinant Methioninase on Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer.- Total Methionine Restriction Treatment of Cancer.- Methioninase Gene Therapy.- Selenomethionine and Methioninase: Selenium Free Radical Anti-Cancer Activity.- Super and Toxicity of Recombinant Methioninase and Polyethylene Glycol (PEG) Recombinant Methioninase in Primates.- Pilot Phase 1 Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine.- Methionine Gamma Lyase from Clostridium sporogenes Increases the Anti-Cancer Effect of Doxorubicin in A549 Cancer Cells In Vitro and Human Cancer Xenografts.- Methionine Restriction and Life-Span Extension.- L-[methyl-11C] Methionine-Positron Emission Tomography (MET PET).- Is the Hoffman Effect for Methionine Overuse Analogous to the Warburg Effect for Glucose Overuse in Cancer?.- Recombinant Methioninase as a DNA Demethylation Agent.- Homocysteine, Thioretinaco Ozonide and Oxidative Phosphorylation in Cancer and Aging: A Proposed Clinical Trial