Methods of Cancer Diagnosis, Therapy and Prognosis

PART I GENERAL METHODS AND OVERVIEWS 1.1. METABOLIC TRANSFORMATIONS OF MALIGNANT CELLS (AN OVERVIEW) Leslie C. Costello and Renty B. Franklin INTRODUCTIONDEFINING A MALIGNANT CELL: A PARASITIC EXISTENCETHE IN SITU ENVIRONMENT OF THE MALIGNANT CELL DICTATES ITS METABOLISMTUMOR CELL PROLIFERATION: METABOLIC PATHWAYS FOR ITS ACHIEVEMENTCOUPLING OF GLYCOLYSIS VIA CITRATE TO DE NOVO LIPOGENESIS/CHOLESTEROGENESISOPERATION OF THE KREBS CYCLE IN TUMOR CELLSGLUTAMINOLYSIS AS AN ALTERNATE OR ADDITIONAL PATHWAY IN TUMOR CELLSOPERATION OF THE KREBS CYCLE IN TUMOR CELLSAPPLICATION OF MOLECULAR GENETICS AND PROTEOMICS TO TUMOR CELL INTERMEDIARY METABOLISMACKNOWLEDGEMENTREFERENCES 1.2. IMAGING TO DETECT RECURRENT CANCER S.J. Gwyther INTRODUCTIONLUNG CANCERBREAST CANCERCOLORECTAL CANCERLYMPHOMASPANCREATIC CANCERPROSTATE CANCERGYNECOLOGICAL CANCERSOvarian CancerEndometrial CancerCervical CancerHEAD AND NECK CANCERSTHYROID CANCERRENAL AND BLADDER TUMORSPRIMARY INTRACRANIAL TUMORSCONCLUSIONS REFERENCES 1.3. TUMOR GENE THERAPY: MAGNETIC RESONANCE IMAGING AND MAGNETIC RESONANCE SPECTROSCOPY Mikko I. Kettunen and Olli H.J. Grohn INTRODUCTIONTUMOR GENE THERAPYMAGNETIC RESONANCE IMAGINGEndogenous Magnetic Resonance Imaging ContrastExogenous Contrast AgentsMAGNETIC RESONANCE SPECTROSCOPYDETECTION OF TRANSGENE DELIVERY AND EXPRESSION USING MAGNETIC RESONANCE IMAGING AND SPECTROSCOPYDETECTION OF GENE THERAPY RESPONSE USING MAGNETIC RESONANCE IMAGING AND SPECTROSCOPYVolumetric ImagingEndogenous ContrastsSodium Magnetic Resonance ImagingMolecular ImagingMagnetic Resonance Spectroscopy of Metabolic AlterationsSUMMARYREFERENCES 1.4. ASSESSMENT OF GENE TRANSFER: MAGNETIC RESONANCE IMAGING AND 18F-FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY Annette Altman and Uwe Haberkorn INTRODUCTIONMOLECULAR IMAGING MODALITIES FOR GENE EXPRESSIONMOLECULAR IMAGING OF SUICIDE GENE TRANSFER AND THERAPEUTIC EFFECTSMOLECULAR IMAGING SUBSTRATE UPTAKE AFTER SUICIDE GENE TRANSDUCTIONNONINVASIVE IMAGING OF

"Once more Professor Hayat has to be congratulated for bringing together 56 leading scientists representing 16 countries in the field of breast cancer, which has made it possible to publish such an excellent book. It represents a valuable addition to the available literature on breast cancer treatment since it covers all aspects of breast cancer, including diagnosis, treatments, and prognosis. Thereby, not only efficacy of various anticancer drugs and their side-effects are pointed out, but also the necessity of age-dependent breast cancer strategies is highlighted. Therefore, I conclude that this book is a true benefit to all clinicians, surgeons, and oncologists working in the field of breast cancer."