Microfluidics
An Application of Physics in Medicine
(Sprache: Englisch)
The mechanical properties of cells are often an indicator of disease. Red blood cells (RBCs) are easily deformable, thus its viability depends greatly on its extracellular medium. In this book, a microfluidic channel with the top wall decorated by a...
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The mechanical properties of cells are often an indicator of disease. Red blood cells (RBCs) are easily deformable, thus its viability depends greatly on its extracellular medium. In this book, a microfluidic channel with the top wall decorated by a periodic array of rigid diagonal ridges that can sort RBCs with different stiffness is presented. It can give rise to a stiffness-dependent force, thus induce transverse separation. RBCs with extracellular media of 0.89% and 0.59% sodium chloride concentrations are separated. By bathing RBCs to various salt concentrations, its shape morphology and also its viscoelastic properties change. The total RBC count also correlated with the %salinity concentrations. These findings support observations relating salinity in blood with RBC count in physiological conditions. With a flow rate of 0.02mL/min and cell concentration of 3.2 x 1010cells/mL, the outlets of the microfluidic device were able to collect RBCs with a total retention of 78%. The analysis should help shed light to the role of physics in medicine. Microfluidics can be an approach to a powerful clinical tool for blood analysis and supplementary tool for disease detection method.
Autoren-Porträt von Clare Maristela V. Galon, Rommel G. Bacabac
V. Galon, Clare MaristelaI am a physics professor at Cebu Normal University. My research field includes but not limited to Medical BioPhysics and Nuclear Physics. I earned my Bachelor's degree in Applied Physics and Master's degree in Physics at University of San Carlos. Aside from my love in science, I also love traveling, doing extreme activities, art, and volunteering.
Bibliographische Angaben
- Autoren: Clare Maristela V. Galon , Rommel G. Bacabac
- 2019, 60 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 6200299382
- ISBN-13: 9786200299383
Sprache:
Englisch
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