Molecular mechanisms of photo-oxidative damage in cells
The role of photo-generated singlet oxygen and reactive hydroperoxides
(Sprache: Englisch)
Living organisms are continually exposed to oxidants. During oxidative stress, reactions of oxidants with biological macromolecules can result in both direct damage and the formation of long-lived, reactive, hydroperoxides. The series of studies undertaken...
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Living organisms are continually exposed to oxidants. During oxidative stress, reactions of oxidants with biological macromolecules can result in both direct damage and the formation of long-lived, reactive, hydroperoxides. The series of studies undertaken in this work focused on the early cellular events following generation of reactive singlet oxygen (1O2) and identified that long-lived protein hydroperoxides, a major product of protein oxidation, can play a significant role in cellular damage by selectively targeting both low-molecular mass and protein thiols. These findings are invaluable in providing an insight of the early molecular events of oxidative stress and a cornerstone for future research in developing a better strategy to prevent oxidative damage.
Bibliographische Angaben
- Autoren: Aldwin Suryo Rahmanto , Michael Davies
- 2011, 284 Seiten, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 3844327126
- ISBN-13: 9783844327120
Sprache:
Englisch
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