Molecular Mechanisms of Spondyloarthropathies
(Sprache: Englisch)
This book provides an overview of Spondyloarthropathies(SpA) and highlights current studies concerning the basic research in the area. It reflects the state of the art of research and current opinion of rheumatologists and immunologists.
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This book provides an overview of Spondyloarthropathies(SpA) and highlights current studies concerning the basic research in the area. It reflects the state of the art of research and current opinion of rheumatologists and immunologists.
Klappentext zu „Molecular Mechanisms of Spondyloarthropathies “
It is now over ten years since we edited the first edition of HLA-B27 in the Development of Spondyloarthropathies (SpA). It is obvious that over this period an enormous amount of information concerning SpA and HLA-B27 has accumulated, and this has been reflected in the knowledge of molecular mechanism of the spondyloarthropathies. Discussion for such a book took initial form at the outstanding 4th Gent Symposium on SpA in October 2006, but was not formally commissioned by Landes Bioscience until early 2007. Molecular Mechanisms of Spondyloarthropathies aims to synthesize this growing knowledge and present all the current studies concerning the basic research of SpA.Over the last decade, enormous progress has been made in the understanding of the molecular and cellular processes that lead to disease pathology. Recognition of the pathways involved in the pathogenic mechanisms of disease and the potential to target specific immune effector functions have opened the door to a wide range of innovative treatment opportunities for the SpA. Thus, we believe that the understanding of the specific molecular mechanisms involved would help to design highly specific drugs in the future. The contributors are among the best in their field and reflect the state of the art of research and current opinion of rheumatologists and immunologists.
Inhaltsverzeichnis zu „Molecular Mechanisms of Spondyloarthropathies “
1. Clinical Assessment in the Spondyloarthropathies 1Ruth Wittoek and Herman Mielants
Abstract 1
Introduction 1
Ankylosing Spondylitis 2
Psoriatic Arthritis 9
2. Imaging in Spondyloarthritis 17
Walter P. Maksymowych
Abstract 17
Introduction 17
Plain Radiography. 18
Computed Tomography 21
Isotopic Imaging 21
Ultrasound 22
Magnetic Resonance Imaging. 22
Sacroiliac Joint 24
Spine 27
Conclusions 33
3. Spondyloarthritis, Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Chondrocalcinosis 37
Jácome Brüges Armas, Ana Rita Couto and Bruno Filipe Bettencourt
Abstract 37
Introduction 37
Spondyloarthritis 37
Diffuse Idiopathic Skeletal Hyperostosis (DISH) 40
Chondrocalcinosis/Crystal Deposition Disease (Cppd CD) 40
Molecular Genetics 42
Conclusions 47
4. The Enthesis Organ Concept and its Relevance to the Spondyloarthropathies. 57
Michael Benjamin and Dennis McGonagle
Abstract 57
Introduction 58
Enthesis Organ Structure 58
Mechanisms for Reducing Stress Concentration at the Enthesis Itself. 63
Related Concepts 66
Conclusions 67
5. Synovial and Mucosal Imunopathology in Spondyloarthritis 71
Bernard Vandooren, Paul P. Tak and Dominique Baeten
Abstract 71
Introduction 71
Axial Versus Peripheral Spondyloarthritis 73
Skeletal Remodeling in Spondyoarthritis 73
Synovial Biomarkers in Spondyoarthritis 75
Gut Inflammation in Spondyloarthritis. 76
The Pathogenesis of Spondyloarthritis: The Mucosa Hypothesis 77
Innate Immunity and Mucosal Inflammation 77
Adaptive Immunity and Mucosal Inflammation 78
The Pathogenesis of Joint Inflammation 78
Conclusions 79
6. Bone Loss in theSpondyloarthropathies: Role of Osteoclast, Rankl, Rank and Opg in the Spondyloarthropathies 85
Allen P. Anandarajah and Edward M. Schwarz
Abstract 85
Introduction 85
Pathogenesis of Bone Loss 86
Bone Loss in the Spondyloarthritis 91
Bone Loss in Ankylosing Spondylitis 91
Bone Loss in PsA 93
Bone Loss in Enteropathic Arthritis 93
Bone Loss in Reactive
... mehr
Arthritis 95
Conclusions 95
7. RankL/Rank as Key Fa ctors for Osteoclast Development and Bone Loss in Arthropathies 100
Andreas Leibbrandt and Josef M. Penninger
Abstract 100
Introduction 100
Basic Characteristics of the Rankl-Rank-Opg Axis 101
RANKL-RANK-OPG Interactions and Bone Remodeling. 104
RANK(L) Signaling Pathways 104
Modulators of Rankl-Mediated Osteoclastogenesis 107
Rank-Rankl as Therapeutic Targets for Arthropathies. 109
Conclusions 110
8. Bone Formation Versus Bone Resorption in Ankylosing Spondylitis. 114
Georg Schett
Abstract 114
Introduction 114
Lessons from Rheumatoid Arthritis 114
Structural Damage in Ankylosing Spondylitis 115
Mechanism of Joint Formation-Molecular Lessons for Joint Fusion. 115
Bony Protrusion as a Stress Response of the Joint 115
Osteoblast-the Bone Forming Cells 116
From the Osteoblast to the Osteophyte 116
Molecular Regulation of Osteophytes. 116
Concepts of Osteophyte Formation 117
Why do Osteophytes Grow in aS and not in ra? 118
Conclusions 120
9. Biomarkers in Spondyloarthropathies 122
Chun-Hsiung Chen, David Tak Yan Yu and Chung-Tei Chou
Abstract 122
Introduction 122
Purpose of Developing Biomarkers in Ankylosing Spondyltis 122
How do Investigators Assess the Degree of Usefulness of Spondylitis Biomarkers? 125
Conclusions 95
7. RankL/Rank as Key Fa ctors for Osteoclast Development and Bone Loss in Arthropathies 100
Andreas Leibbrandt and Josef M. Penninger
Abstract 100
Introduction 100
Basic Characteristics of the Rankl-Rank-Opg Axis 101
RANKL-RANK-OPG Interactions and Bone Remodeling. 104
RANK(L) Signaling Pathways 104
Modulators of Rankl-Mediated Osteoclastogenesis 107
Rank-Rankl as Therapeutic Targets for Arthropathies. 109
Conclusions 110
8. Bone Formation Versus Bone Resorption in Ankylosing Spondylitis. 114
Georg Schett
Abstract 114
Introduction 114
Lessons from Rheumatoid Arthritis 114
Structural Damage in Ankylosing Spondylitis 115
Mechanism of Joint Formation-Molecular Lessons for Joint Fusion. 115
Bony Protrusion as a Stress Response of the Joint 115
Osteoblast-the Bone Forming Cells 116
From the Osteoblast to the Osteophyte 116
Molecular Regulation of Osteophytes. 116
Concepts of Osteophyte Formation 117
Why do Osteophytes Grow in aS and not in ra? 118
Conclusions 120
9. Biomarkers in Spondyloarthropathies 122
Chun-Hsiung Chen, David Tak Yan Yu and Chung-Tei Chou
Abstract 122
Introduction 122
Purpose of Developing Biomarkers in Ankylosing Spondyltis 122
How do Investigators Assess the Degree of Usefulness of Spondylitis Biomarkers? 125
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Autoren-Porträt
CARLOS LÓPEZ-LARREA is Professor of Immunology (UC M, Madrid, Spain) and currently Head of the Histocompatiblity Unit at the "Hospital Universitario Central de Asturias" (Oviedo, Spain). He is a world expert on spondyloarthropathies (SpA), in particular genetic (MHC) and immunologic factors that influence the development of SpA. His primary research is focused on understanding the role of HLA-B27 polymorphism in the development of ankylosing spondylitis (AS), and describing relevant associations of B27 subtypes with AS in large extended worldwide populations. In the last decade, the availability of HLA-B27 subtypes differentially associated with the disease has provided a unique tool for exploring the relationship between peptide specificity and pathogenetic potential. The main research interests of his group currently include the role of innate immunity (NKs) in SpA. He is a member of several national and international scientific organizations. It is now over ten years since the first edition of HLA-B27 in the Developement of Spondyloarthropathies (SpA) was published and edited by C. López-Larrea. This current book aims to synthesize the growing knowledge in the field and present all current studies concerning basic research in SpA. ROBERTO DÍAZ -PEÑA is a predoctoral investigator in the Histocompatibility Unit of the Department of Immunology, Hospital Universitario Central de Asturias. He graduated in biochemistry, at the University of Oviedo, Spain. His main research interests include the genetics of spondyloarthropathies, especially ankylosing spondylitis, and the role of inhibitory and activating KIR receptors in this disease.
Bibliographische Angaben
- 2014, 2009, XXV, 314 Seiten, Maße: 15,5 x 23,5 cm, Kartoniert (TB), Englisch
- Herausgegeben: Carlos López-Larrea, Roberto Díaz-Peña
- Verlag: Springer, Berlin
- ISBN-10: 1489990259
- ISBN-13: 9781489990259
Sprache:
Englisch
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