Molecular Profiling

Tumor Staging and Grading: A Primer.-Clinical Trial Design in the Age of Molecular Profiling.-Personalized Medicine: Ethics for Clinical Trials.-Reduction of Preanalytical Variability in Specimen Procurement for Molecular Profiling.-The Human Side of Cancer Biobanking.-Introduction to Genomics.-Genomic Profiling: cDNA arrays and oligoarrays.-Genome wide methylation profiling in archival formalin fixed paraffin embedded (FFPE) tissue samples.-An Overview of microRNA Methods: Expression Profiling and Target Identification.-Antibody Validation by Western Blotting.-Laser Capture Microdissection: ArcturusXT infra-red capture and UV cutting methods.-Antibody microarrays: Analysis of Cystic Fibrosis.-Tissue Microarrays As A Tool In The Discovery & Validation Of Predictive Biomarkers.-Reverse phase protein microarrays.-Serum Low Molecular Weight Protein Fractionation for Biomarker Discovery.-Mass spectrometry based biomarker discovery.-Mitochondrial Proteome: Toward The Detection and Profiling of Disease Associated Alterations.-Adult Neural Stem Cells: Isolation and Propagation.-Evanescent Wave Imaging: An Introduction to Total Internal Reflection Fluorescence Microscopy (TIRF).-Construction and Hyperspectral Imaging of Quantum Dot Lysate Arrays.-Microarray Data Analysis: Comparing Two Population Means.-Bioinformatics/Biostatistics: microarray analysis.-Structure-based functional design of drugs: from target to lead compound.-Personalized Medicine: Changing the Paradigm of Drug Development.-Grant Writing Tips for the First Time Applicant.-Inventions and Patents: A practical tutorial.-Regulatory Approval Pathways for Molecular Diagnostic Technology.-Small business development for molecular diagnostics.

From the reviews:"This informative book combines genomics, proteomics, and bioinformatics with experimental protocols and detailed discussions regarding future challenges in commercialization and practical use in the field with an emphasis on tissue-based molecular profiling. ... readers can use this as a practical guide at the laboratory bench as well as in the boardroom. The book is written for scientists, pathologists, oncologists, biotechnologists, residents, medical students, and nurses involved in clinical trial research. ... This will be a valuable tool for those involved in clinical trial research." (Omer Iqbal, Doody's Book Reviews, April, 2012)