Muscle Relaxants

'1. History of Muscle Relaxants.- Some Early Approaches to Relaxation in the United Kingdom.- The Final Steps Leading to the Anesthetic Use of Muscle Relaxants 8/TOC.- History of Muscle Relaxants in Japan.- 2. The Neuromuscular Junctions - Update.- Mechanisms of Action of Reversal Agents.- Nicotinic Recentors.- The Neuromuscular Junction - Basic Receptor Pharmacology.- Muscle Contraction and Calcium Ion.- 3. Current Basic Experimental Works Related to Neuromuscular Blockade in Present and Future.- Preiunctional Actions of Neuromuscular Blocking Drugs.- Approaches to Short-Acting Neuromuscular Blocking Agents.- Effects Other than Relaxation of Non-Depolarizing Muscle Relaxants.- Regulation of Innervation-Related Properties of Cultured Skeletal Muscle Cells by Transmitter and Co-Transmitters.- 4. Current Clinical Experimental Works Related to Neuromuscular Blockade in Present and Future.- Where Should Experimental Works Be Conducted?.- Muscle Relaxants in the Intensive Care Unit.- New Relaxants in the Operating Room.- Kinetic-Dynamic Modelling of Neuromuscular Blockade.- 5. Basic Aspects of Neuromuscular Junction.- Physiology of the Neuromuscular Junction.- Properties of ?7-Containing Acetylcholine Receptors and Their Expression in Both Neurons and Muscle.- Molecular Biology of Neuromuscular Transmission.- Presynaptic Neuromuscular Blockade.- The Function of the ACh Receptor Channel.- 6. Onset of Action.- Differences of Onset of Different Muscles in Man and Their Consequences on Monitoring of Neuromuscular Transmission.- Structure-Onset Relationship of Steroidal Neuromuscular Blocking Agents.- A Blueprint for a Fast Acting Non-Depolarizing Drug.- 7. Relaxants in ICU.- Benzylisoquinolinium Compounds in the Critically Ill Patient.- The Long-Term Use of Pipecuronium in Cardiac and Esophageal Surgery Patients.- Mechanisms - Changes Induced by Long-Term High-Dose Muscle Relaxant Administration.- 8. Pharmacokinetics, Metabolism, and Metabolites.- Metabolism and Metabolites