Neurodegeneration
(Sprache: Englisch)
Neurodegenerative disorders, such as Alzheimer's and Parkinson's disease are a growing burden on our society. Understanding and treating these common diseases is one of the major current challenges for the biomedical field. In Neurodegeneration: Methods and...
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Neurodegenerative disorders, such as Alzheimer's and Parkinson's disease are a growing burden on our society. Understanding and treating these common diseases is one of the major current challenges for the biomedical field. In Neurodegeneration: Methods and Protocols, experts in the field tackle this challenge and present cutting-edge analytical and technological approaches to study the mechanisms underlying neurodegenerative processes. Organizes into five sections, chapters detail protocols for isolating and culturing cells from the nervous system, production and use of animal models, characterization of cell death, analytical tools to study disease mechanisms, and therapeutic approaches for neurodegeneration. Written in the successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.
Authoritative and easily accessible, Neurodegeneration: Methods and Protocols serves as an ideal guide to both novice and professional researchers in the field of neurodegeneration.
Authoritative and easily accessible, Neurodegeneration: Methods and Protocols serves as an ideal guide to both novice and professional researchers in the field of neurodegeneration.
Klappentext zu „Neurodegeneration “
Neurodegenerative disorders, such as Alzheimer's and Parkinson's disease are a growing burden on our society. Understanding and treating these common diseases is one of the major current challenges for the biomedical field. In Neurodegeneration: Methods and Protocols, experts in the field tackle this challenge and present cutting-edge analytical and technological approaches to study the mechanisms underlying neurodegenerative processes. Organizes into five sections, chapters detail protocols for isolating and culturing cells from the nervous system, production and use of animal models, characterization of cell death, analytical tools to study disease mechanisms, and therapeutic approaches for neurodegeneration. Written in the successful Methods in Molecular Biology¿ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.Authoritative and easily accessible, Neurodegeneration: Methods and Protocols serves as an ideal guide to both novice and professional researchers in the field of neurodegeneration.
Inhaltsverzeichnis zu „Neurodegeneration “
Part I. Neurodegeneration1. Introduction to Neurodegenerative Diseases and Related Techniques
Hibiki Kawamata and Giovanni Manfredi
2. In vivo and In vitro Determination of Cell Death Markers in Neurons
Nicole Naniche, Daniela Sua, and Piera Pasinelli
3. Degenerating Processes Identified by Electron Microscopic Immunocytochemical Methods
Teresa A. Milner, Elizabeth M. Waters, Danielle C. Robinson, and Joseph P. Pierce
Part II. Neural Cell Culture Techniques
4. Isolation and Culture of Neurons and Astrocytes from the Mouse Brain Cortex
Hyun-Jeong Kim and Jordi Magrané
5. Isolation and Culture of Postnatal Spinal Motoneurons
Carol Milligan and David Gifondorwa
6. Converting Human Pluripotent Stem Cells to Neural Tissue and Neurons to Model Neurodegeneration
Stuart M. Chambers, Yvonne Mica, Lorenz Studer, and Mark J. Tomishima
7. Neural Differentiation of Induced Pluripotent Stem Cells
Mark Denham and Mirella Dottori
Part III. Models of Neurodegeneration
8. Developing Yeast Models of Human Neurodegenerative Disorders
Alejandro Ocampo and Antoni Barrientos
9. Modeling Dopamine Neuron Degeneration in C. elegans
Michelle L. Tucci, Adam J. Harrington, Guy A. Caldwell, and Kim A. Caldwell
10. Role of the Proteasome in Fly Models of Neurodegeneration
Chun-Hung Yeh, Marlon Jansen, and Thomas Schmidt-Glenewinkel
11. Modeling Neurodegenerative Diseases in Zebrafish Embryos
Angela Laird and Wim Robberecht
12. Practical Considerations of Genetic
... mehr
Rodent Models for Neurodegenerative Diseases
Kindiya Geghman and Chenjian Li
13. Modeling Focal Cerebral Ischemia In vivo
Katherine Jackman, Alexander Kunz, and Costantino Iadecola
14. Pharmacological Models of Parkison's Disease in Rodents
Peter Klivenyi and Laszlo Vecsei
15. Behavioral Phenotyping of Mouse Models of Neurodegeneration
Magali Dumont
Part IV. Neurodegenerative Disease Mechanisms - Proteinopathies
16. Characterization of Amyloid Deposits in Neurodegenerative Diseases
Ruben Vidal and Bernardino Ghetti
17. Detection of Protein Aggregates in Neurodegenerative Diseases
Han-xiang Deng, Eileen H. Bigio, and Teepu Siddique
18. Assessment of Proteasome Impairment and Accumulation/Aggregation of Ubiquitinated Proteins in Neuronal Cultures
Natura Myeku, Maria Jose Metcalfe, Qian Huang, and Maria Figueiredo-Pereira
Part V. Neurodegenerative Disease Mechanisms - Mitochondria
19. Measurements of Threshold of Mitochondrial Transition Pore Opening in Intact and Permeabilized Cells by Flash Photolysis of Caged Calcium
Andrey Y. Abramov and Michael R. Duchen
20. Isolation and Functional Assessment of Mitochondria from Small Amounts of Mouse Brain Tissue
Christos Chinopoulos, Steven F. Zhang, Bobby Thomas, Vadim Ten, and Anatoly A. Starkov
21. Monitoring Mitophagy in Neuronal Cell Cultures
Jianhui Zhu, Ruben K. Dagda, and Charleen T. Chu
Part VI. Neurodegenerative Disease Mechanisms - Biological functions
22. Analysis of Vesicular Trafficking in Primary Neurons by Live Imaging
Davide Tampellini and Gunnar K. Gouras
23. Surface Trafficking of Sodium Channels in Cells and in Hippocampal Slices
Doo Yeon Kim and Dora M. Kovacs
24. Imaging Presynaptic Exocytosis in Corticostriatal Slices
Minerva Yue, David Sulzer, and Nigel Bamford
25. Microscopic Imaging of Intracellular Calcium in Live Cells using Lifetime based Ratiometric Measurements of Oregon Green BAPTA-1
Carli Lattarulo, Diana Thyssen, Kishore V. Kuchibholta, Bradley T. Hyman, and Brian J. Bacskai
26. Electrophysiological Characterization of Neuromuscular Synaptic Dysfunction in Mice
Yoshie Sugiura and Weichun Lin
27. Determination of Neurotransmitter Levels in Models of Parkinson's Disease by HPLC-ECD
Lichuan Yang and Flint M. Beal
28. Designing, Performing, and Interpreting a Microarray-based Gene Expression Study
Giovanni Coppola
Part VII. Therapeutic Approaches in Neurodegeneration
29. Adeno-associated Viral Gene Transfer for Neurodegenerative Diseases
Peter F. Morgenstern, Roberta Marongiu, Sergei A. Musatov, and Michael G. Kaplitt
30. Specific Gene Silencing using RNAi in Cell Culture
Chunxing Yang, Linghua Qiu, and Zuoshang Xu
31. Stem Cell Transplantation for Spinal Cord Neurodegeneration
Angelo C. Lepore and Nicholas J. Maragakis
32. Evaluation of Histone Deacetylase Inhibitors as Therapeutics for Neurodegenerative Diseases
Elisabetta Soragni, Chunping Xu, Andrew Cooper, Heather L. Plasterer, James R. Rusche, and Joel M. Gottesfeld
Kindiya Geghman and Chenjian Li
13. Modeling Focal Cerebral Ischemia In vivo
Katherine Jackman, Alexander Kunz, and Costantino Iadecola
14. Pharmacological Models of Parkison's Disease in Rodents
Peter Klivenyi and Laszlo Vecsei
15. Behavioral Phenotyping of Mouse Models of Neurodegeneration
Magali Dumont
Part IV. Neurodegenerative Disease Mechanisms - Proteinopathies
16. Characterization of Amyloid Deposits in Neurodegenerative Diseases
Ruben Vidal and Bernardino Ghetti
17. Detection of Protein Aggregates in Neurodegenerative Diseases
Han-xiang Deng, Eileen H. Bigio, and Teepu Siddique
18. Assessment of Proteasome Impairment and Accumulation/Aggregation of Ubiquitinated Proteins in Neuronal Cultures
Natura Myeku, Maria Jose Metcalfe, Qian Huang, and Maria Figueiredo-Pereira
Part V. Neurodegenerative Disease Mechanisms - Mitochondria
19. Measurements of Threshold of Mitochondrial Transition Pore Opening in Intact and Permeabilized Cells by Flash Photolysis of Caged Calcium
Andrey Y. Abramov and Michael R. Duchen
20. Isolation and Functional Assessment of Mitochondria from Small Amounts of Mouse Brain Tissue
Christos Chinopoulos, Steven F. Zhang, Bobby Thomas, Vadim Ten, and Anatoly A. Starkov
21. Monitoring Mitophagy in Neuronal Cell Cultures
Jianhui Zhu, Ruben K. Dagda, and Charleen T. Chu
Part VI. Neurodegenerative Disease Mechanisms - Biological functions
22. Analysis of Vesicular Trafficking in Primary Neurons by Live Imaging
Davide Tampellini and Gunnar K. Gouras
23. Surface Trafficking of Sodium Channels in Cells and in Hippocampal Slices
Doo Yeon Kim and Dora M. Kovacs
24. Imaging Presynaptic Exocytosis in Corticostriatal Slices
Minerva Yue, David Sulzer, and Nigel Bamford
25. Microscopic Imaging of Intracellular Calcium in Live Cells using Lifetime based Ratiometric Measurements of Oregon Green BAPTA-1
Carli Lattarulo, Diana Thyssen, Kishore V. Kuchibholta, Bradley T. Hyman, and Brian J. Bacskai
26. Electrophysiological Characterization of Neuromuscular Synaptic Dysfunction in Mice
Yoshie Sugiura and Weichun Lin
27. Determination of Neurotransmitter Levels in Models of Parkinson's Disease by HPLC-ECD
Lichuan Yang and Flint M. Beal
28. Designing, Performing, and Interpreting a Microarray-based Gene Expression Study
Giovanni Coppola
Part VII. Therapeutic Approaches in Neurodegeneration
29. Adeno-associated Viral Gene Transfer for Neurodegenerative Diseases
Peter F. Morgenstern, Roberta Marongiu, Sergei A. Musatov, and Michael G. Kaplitt
30. Specific Gene Silencing using RNAi in Cell Culture
Chunxing Yang, Linghua Qiu, and Zuoshang Xu
31. Stem Cell Transplantation for Spinal Cord Neurodegeneration
Angelo C. Lepore and Nicholas J. Maragakis
32. Evaluation of Histone Deacetylase Inhibitors as Therapeutics for Neurodegenerative Diseases
Elisabetta Soragni, Chunping Xu, Andrew Cooper, Heather L. Plasterer, James R. Rusche, and Joel M. Gottesfeld
... weniger
Bibliographische Angaben
- XV, 512 Seiten, 9 farbige Abbildungen, 93 Schwarz-Weiß-Abbildungen, Maße: 18,3 x 26 cm, Gebunden, Englisch
- Herausgegeben: Giovanni Manfredi, Hibiki Kawamata
- Verlag: Springer-Verlag GmbH
- ISBN-10: 1617793272
- ISBN-13: 9781617793271
- Erscheinungsdatum: 15.09.2011
Sprache:
Englisch
Rezension zu „Neurodegeneration “
From the reviews:"This is an authoritative collection of manuscripts tailored to bench scientists involved in neurodegenerative research. ... It is intended for cell biologists, molecular biologists, biochemists, pathologists, and researchers in the field of neurodegeneration. ... This book is most appropriate for the audience of basic scientists interested in the mechanics of experimental neurodegenerative work. For this audience, the book will find a suitable space on their lab benches." (Joseph I. Sirven, Doody's Book Reviews, April, 2012)
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