SpringerBriefs in Biochemistry and Molecular Biology / NF- B-Related Genetic Diseases
(Sprache: Englisch)
This book presents the diverse clinical, cellular and molecular manifestations of NF-KB-related genetic diseases. It shows that studying patient-related pathologies affecting the components of the NF-KB signaling pathway offers the opportunity to understand...
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Klappentext zu „SpringerBriefs in Biochemistry and Molecular Biology / NF- B-Related Genetic Diseases “
This book presents the diverse clinical, cellular and molecular manifestations of NF-KB-related genetic diseases. It shows that studying patient-related pathologies affecting the components of the NF-KB signaling pathway offers the opportunity to understand the various functions of NF-KB in humans, complementing studies performed with mouse models. In addition, people treating those patients acquire a deeper understanding of the molecular basis of the pathophysiological processes.Inhaltsverzeichnis zu „SpringerBriefs in Biochemistry and Molecular Biology / NF- B-Related Genetic Diseases “
1) The NF-kB signaling pathways: players and Functions.- 2) Genetic Diseases Affecting the Canonical Pathway of NF-kB Activation.- 3) Genetic Diseases Affecting hte Non-Camonical Pathway of NF-kB Activation.- 4) Genetic Diseases Affecting Ubiquitination Processes in NF-kB Signaling.- 5)Lessons Learned from Studying NF-kB Related Genetic Diseases.
Autoren-Porträt von Gilles Courtois, Alessandra Pescatore, Jérémie Gautheron, Francesca Fusco, Matilde Valeria Ursini, Anna Senegas
Gilles Courtois (INSERM) and colleagues are performing genetic research at the Institut des Neurosciences de Grenoble. They have demonstrated details of the NF-kB signaling pathway and collaborate on publications about Incontinentia Pigmenti, a genetic disease of the skin, hair, teeth and central nervous system. He and his team are working with the group of Annie Andrieux and Eric Denarier on mice lacking the NEMO protein, one component of the signal cascade, exclusively in their nervous system or throughout their body. The studies focus on neurological problems but will provide insight into the signaling pathway from different angles.
Bibliographische Angaben
- Autoren: Gilles Courtois , Alessandra Pescatore , Jérémie Gautheron , Francesca Fusco , Matilde Valeria Ursini , Anna Senegas
- 2016, 1st ed. 2016, XII, 70 Seiten, Maße: 15,5 x 23,5 cm, Kartoniert (TB), Englisch
- Verlag: Springer, Berlin
- ISBN-10: 3319258486
- ISBN-13: 9783319258485
- Erscheinungsdatum: 08.02.2016
Sprache:
Englisch
Pressezitat
"This book provides essential concepts in the understanding of the impact of deregulated NF-kappaB activation on human health. ... This book is intended for molecular biologists, human geneticists, and students interested in learning more about NF-kappaB signaling and its impact on human disease. The book is also useful for pathologists and clinicians interested in understanding more about this topic. ... Several color illustrations help in the understanding of this complex subject." (Omer Iqbal, Doody's Book Reviews, April, 2016)
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