Pediatric Germ Cell Tumors

Biology of Germ Cell Tumors.-Epidemiology of Germ Cell Tumors.-Pathology of Germ Cell Tumors.-Clinical Treatment of Extracaranial Pediatric Germ Cell Tumors.-Clinical Treatment of Extracranial Pediatric Germ Cell Tumors.-Management of Disseminated Germ Cell Tumor in Adults.-Clinical Treatment of Adult Women with Ovarian Germ Cell Tumors.-Stromal Cell Tumors.-Late Effects of Treatment of Testicular Cancer and Implications for Pediatrics.

Dr. A. Lindsay Frazier, MD, received her MD from Dartmouth Medical School in 1984, followed by a pediatric residency at Children's Hospital Boston and a pediatric hematology-oncology fellowship at DFCI, where she joined the faculty in 1990. She received a ScM from Harvard School of Public Health in 1993. In clinical practice, she concentrates on germ cell tumors.  She has served on the steering committee of the Children's' Oncology Group's (COG) germ cell committee since 1996. Since 2008, she has assumed overall leadership of the germ cell tumor committee at COG, which entails oversight of all current protocols and development of the strategic initiatives for future protocols across the spectrum of disease from low risk to high risk to salvage therapies. Interested in promoting the study of the biologic and epidemiologic origins of GCT, she has been instrumental in recruiting collaborators with these foci to join the COG steering committee. She spearheaded an international collaboration with the Children's Cancer and Leukemia Group in the United Kingdom to combine their clinical datasets from the last 25 years constructing an international risk classification system that will serve as the basis for joint international clinical trials.

Dr. James Amatruda is Assistant Professor of Pediatrics, Molecular Biology and Internal Medicine at The University of Texas Southwestern Medical Center, Dallas, Texas.  He is the Horchow Family Endowed Scholar in Pediatrics at UT Southwestern and an Attending Physician in the Center for Cancer and Blood Disorders at Children's Medical Center in Dallas, Texas. Dr. Amatruda received his undergraduate degree from Harvard University, and his M.D. and Ph.D. degrees from Washington University in St. Louis.  He received further training in Internal Medicine at the Brigham and Women's Hospital and in Medical Oncology at the Dana-Farber Cancer Institute, Boston.  His post-doctoral training was with Dr. Leonard Zon at Children's Hospital