Pharmaceutical Perspectives of Cancer Therapeutics

1. Tumor microvasculature and microenvironment: Therapeutic targets for inhibition of angiogenesis and metastasis Chikezie Madu and Yi Lu* 2. Anticancer drug development AjitNarang* and Divyakant S. Desai 3. Tumor targeted macromolecular drug delivery based on the enhanced permeability and retention effect in solid tumor Takahiro Seki, Jun Fang, and Hiroshi Maeda* 4. Multidrug-resistance in solid tumor and its reversal Ho Lun Wong*, Xiao Yu Wu, and Reina Bendayan 5. Targeting of apoptosis signaling pathways and their mediators for cancer therapy Arun K. Rishi*, Xinbo Zhang, and Anil Wali 6. Role of telomerase in cancer therapeutics Kyung H. Choi and Michel M. Ouellette* 7. Polymeric carriers for anticancer drug delivery Dongin Kim and You Han Bae* 8. Application of nanobiotechnology in cancer therapeutics Kewal K. Jain 9. Receptor-mediated delivery of proteins and peptides to tumors Christian Dohmen and Manfred Ogris* 10. Protein transduction domain-mediated delivery of anti-cancer proteins Hiroshi Harada* and Masahiro Hiraoka 11. Current therapeutic uses of monoclonal antibodies Michael Axelson and David Gerber* 12. Cancer vaccines ZsuzsannaTabi 13. RNA interference for cancer therapy Kun Cheng* and Bin Qin 14. MicroRNAs as therapeutic targets for cancer Guofeng Cheng, Michael Danquah, and Ram I Mahato* 15. Targeted therapies for malignant brain tumors Matthew A. Tyler, Adam Quasar Sugihara, Ilya V. Ulasov, and Maciej S. Lesniak* 16. The complexity of the HIF-1-dependent hypoxic response in breast cancer presents multiple avenues for therapeutic intervention Tiffany Seagroves 17. Cancer stem cells: potential mediators of therapeutic resistance and novel targets of anti-cancer treatments Hong Yan, Jichao Qin, and Dean G. Tang* 18. Image-guided photodynamic cancer therapy Zheng-Rong Lu* and AnaghaVaidya 19. Functional imaging of multidrug resistance and its applications Célia Gomes 20.Gene expression microarrays in cancer research Jian Yang and Weikuan Gu*

Yi Lu graduated with B.S. in Biochemistry from Fudan University in Shanghai, China in 1984, and Ph.D. in Biochemistry and Molecular Biology from University of Nebraska Medical Center, Omaha, NE, USA in 1992. He is currently an Associate Professor at the Departments of Pathology, Medicine, and Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA. His research interests include tumor angiogenesis and metastasis, gene therapy for prostate cancer and breast cancer, targeted gene expression, and exploration of novel apoptosis-inducing genes. He has more than 50 publications and holds five patents.