Prefoldins: the new chaperones
(Sprache: Englisch)
This book reviews recent work on molecular chaperones of the prefoldin family from their discovery in Archaea to the basic clarification of their structure. Even though, there is still a lot to investigate in order to understand the roles and functions of...
Jetzt vorbestellen
versandkostenfrei
Buch (Gebunden)
109.99 €
- Lastschrift, Kreditkarte, Paypal, Rechnung
- Kostenlose Rücksendung
- Ratenzahlung möglich
Produktdetails
Produktinformationen zu „Prefoldins: the new chaperones “
Klappentext zu „Prefoldins: the new chaperones “
This book reviews recent work on molecular chaperones of the prefoldin family from their discovery in Archaea to the basic clarification of their structure. Even though, there is still a lot to investigate in order to understand the roles and functions of prefoldins, some preliminary work suggests their contribution in assembly and activation of a variety of macromolecular complexes. Hence, the reader is introduced to recent structural findings via cryo-electron microscopy and to the importance of this particular group of proteins in health and disease. This book also discusses the particular structure of the URI prefoldin-like complex. In addition, recent developments in the generation of URI mouse models speculate on the functions and emerging roles of the URI prefoldin-like complex in various cellular processes. This novel protein complex represents a unique cellular machinery, which molecular basis of its activity still remains to be determined.This work is thus a guide to help researchers in the field to have a more comprehensive and critical view of the prefoldin world.
Inhaltsverzeichnis zu „Prefoldins: the new chaperones “
Preface.- Structure of the molecular chaperone prefoldin.- Structure and function of archaeal prefoldin.- Role and functions of prefoldins.- Nuclear functions of prefoldins.- The yeast prefoldin Bud27.- URI-like prefoldin complex.- HSP90 and its R2TP/Prefoldin-like cochaperone.- Role and functions of URI: mouse models for URI.- Nuclear function of URI-like prefoldin complex.- URI and androgen regulation. Index.
Autoren-Porträt
Nabil Djouder obtained his PhD in Molecular Pharmacology from the University of Strasbourg (France) and the University of Freiburg (Germany). In 2001 he moved to Basel (Switzerland) as a postdoctoral research fellow and joined the laboratory of W. Krek at the Novartis Friedrich Miescher Institute. In 2003 he became a member of the Competence Centre for Systems Physiology and Metabolic Diseases (CCSPMD) and in September 2009 he joined the CNIO as a Principal Investigator establishing his group in the field of Growth factors, Metabolism and Cancer.
Bibliographische Angaben
- 2018, 1st ed. 2019, IX, 135 Seiten, 36 farbige Abbildungen, Maße: 18,1 x 26,1 cm, Gebunden, Englisch
- Herausgegeben: Nabil Djouder
- Verlag: Springer, Berlin
- ISBN-10: 3030007367
- ISBN-13: 9783030007362
- Erscheinungsdatum: 14.02.2019
Sprache:
Englisch
Kommentar zu "Prefoldins: the new chaperones"
Schreiben Sie einen Kommentar zu "Prefoldins: the new chaperones".
Kommentar verfassen