Proteostasis and Chaperone Surveillance

Part 1: Maintaining Proteostasis.- 1. Structural Allostery and Protein-Protein Interactions of Sin3.- 2. Protein Posttranslational Modifications: Role in Protein Structure, Function and Stability.- 3. Protein Folding and Aggregation: A revisit of basic conception.- Part 2: Proteopathy: Failure of proteostasis.- 4. Protein Folding: From Normal Cellular Function to Pathophysiology.- 5. Protein Misfolding Diseases: In perspective of Gain and loss-of-function.- 6. Amyloid formation in Alzheimer's disease.- 7. Advances in modulation of Proteopathies, the devil spread from head to toe.- Part 3: Chaperone surveillance of proteopathy.- 8. Small Molecule Osmolytes can Modulate Proteostasis.- 9. Pharmacological Chaperones in Protein Aggregation Disorders.

Dr. Laishram R. Singh is an Assistant Professor in the University of Delhi. He obtained his Master's Degree from Jamia Millia Islamia, New Delhi. After receiving Doctoral degree in protein Biophysics from Jamia Millia Islamia, New Delhi, Dr. Singh continued his postdoctoral research at Fox Chase cancer Center, Philadelphia (FCCC). During his Doctoral study he was engaged in investigating how small molecule compounds affect native protein structure, stability and enzymatic catalysis. At FCCC his main research interest encompasses understanding the Proteostasis and modulators of mutant proteins including, mutants of p53, cystathionine beta synthase and methyl tetrahydrofolate reductase. Currently Dr. Singh (at Delhi University) is working how the dysregulated proteostasis, which is the common hallmark of many neurodegenerative and metabolic disorders, could be reversed. Dr. Singh is a well-known enzymologist and protein biochemist. He has published more than 37 publications in many esteemed journals in the field of proteostatic regulation by small molecules and various heat shock proteins. Dr Singh is also a recipient of Elizabeth Knight Peterson Fellowship sponsored by FCCC, Philadelphia.