The Role of KATP Channels in Models of Midbrain Dopaminergic Neuron Loss
Open Probability Influences Neuron Survival in Vitro
(Sprache: Englisch)
The dopaminergic neurons of the ventral midbrain (mesDA neurons) form several distinct sub-populations which are involved in emotional control, reward behaviour and motor control. In patients with Parkinson's Disease, the dopaminergic neurons of the...
Leider schon ausverkauft
versandkostenfrei
Buch
60.70 €
- Lastschrift, Kreditkarte, Paypal, Rechnung
- Kostenlose Rücksendung
- Ratenzahlung möglich
Produktdetails
Produktinformationen zu „The Role of KATP Channels in Models of Midbrain Dopaminergic Neuron Loss “
Klappentext zu „The Role of KATP Channels in Models of Midbrain Dopaminergic Neuron Loss “
The dopaminergic neurons of the ventral midbrain (mesDA neurons) form several distinct sub-populations which are involved in emotional control, reward behaviour and motor control. In patients with Parkinson's Disease, the dopaminergic neurons of the substantia nigra, pars compacta (SNpc) gradually die. One focus of research has been to find an explanation why the SN pc neurons aremore vulnerable to cellular stress than other neuronal populations. KATP channels consist of Sur 1 or 2 and Kir 6.1 or 6.2 subunits andlink the metabolic state of a cell to its membrane potential. Hypothetically, the normal open-closed state of KATP channels mightinfluence cellular survival when the mesDA neurons are under oxidative stress. In this work, I show that blocking KATP channels in vitro by pharmaceutical means has a positive effect on cellsurvival when mesDA are under oxidative stress. Conversely, for cedactivation of KATP channels under these conditions leads to an increased rate of cell death. This highlights the importance of KATP channel function and may give a new direction in the development of drugs targeting Parkinson's disease.
Autoren-Porträt von Christian Scholz
Christian Scholz studied biology in Darmstadt and Heidelberg and specialized after his diploma in developmental neurobiology and basic research on Parkinson`s Disease. The work presented here discusses the results of his PhD thesis.
Bibliographische Angaben
- Autor: Christian Scholz
- 2008, 132 Seiten, Maße: 15 x 22 cm, Kartoniert (TB), Englisch
- Verlag: VDM Verlag Dr. Müller
- ISBN-10: 3639032195
- ISBN-13: 9783639032192
Sprache:
Englisch
Kommentar zu "The Role of KATP Channels in Models of Midbrain Dopaminergic Neuron Loss"
Schreiben Sie einen Kommentar zu "The Role of KATP Channels in Models of Midbrain Dopaminergic Neuron Loss".
Kommentar verfassen