The Role of Microenvironment in the Control of Tumor Angiogenesis
(Sprache: Englisch)
This work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis.
Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the...
Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the...
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This work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis.Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and requires the functional activities of a number of molecules, including angiogenic factors, extracellular matrix proteins, adhesion molecules and proteolytic enzymes.
In normal tissues, vascular quiescence is maintained by the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli.
Tumor angiogenesis is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors for endothelial cells, that stimulate the growth of the blood vessels of the host or the down-regulation of natural angiogenesis inhibitors.
In particular, the inflammatory infiltrate may contribute to tumor angiogenesis, and there are many reports of associations between tumor inflammatory infiltrate, vascularity and prognosis.
New therapeutic approaches have been developed with the aim to control tumor angiogenesis through targeting of different components of tumor microenvironment.
Inhaltsverzeichnis zu „The Role of Microenvironment in the Control of Tumor Angiogenesis “
Prelims1. Tumor microenvironment
1.1. Metastaticcascade
1.2.Epithelial-mesenchymal transition
1.3. Theextracellular matrix
2. Tumor bloodvessels and tumor endothelial cells
2.1. Tumorbasement membrane2.2. Tumorpericytes
3. Tumorangiogenesis
3.1. Sproutingangiogenesis
3.2. Vascularco-option
3.3.Vasculogenic mimicry
3.4.Intussusceptive microvascular growth
4. Inflammatorycells in tumor microenvironment4.1.Neutrophils
4.2.Eosinophils and dendritic cells
4.3.Lymphocytes and platelets
4.4. Mast cells
4.5. Macrophages
4.6. Tie-2expressing monocytes (TEMs)
4.7. Fibroblasts
4.8. Osteoblasts and osteoclasts4.9. Cancerstem cells (CSCs)
4.10.Circulatingendothelial cells and endothelial precursor cells
4.11. Multipotents adult progenitor cells (MAPCs) and myeloid-derived suppressorcells (MDSCs)
5. Therapeuticstrategies, the concept of "normalization" and the role of VEGF inhibition
Index
Bibliographische Angaben
- Autor: Domenico Ribatti
- 2016, 1st ed. 2016, XI, 86 Seiten, 16 farbige Abbildungen, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Verlag: Springer, Berlin
- ISBN-10: 3319278185
- ISBN-13: 9783319278186
- Erscheinungsdatum: 16.02.2016
Sprache:
Englisch
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