The Role of XBP-1 in Colorectal Cancer Metastasis
(Sprache: Englisch)
The author studied the role of X-Binding Protein (XBP-1) in CRC metastasis. Results indicated that, XBP-1 was expressed at high levels in metastatic and poorly differentiated tissue sample and a relatively low levels in moderately and well differentiated...
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The author studied the role of X-Binding Protein (XBP-1) in CRC metastasis. Results indicated that, XBP-1 was expressed at high levels in metastatic and poorly differentiated tissue sample and a relatively low levels in moderately and well differentiated tissue samples. Moreover, XBP-1 was expressed in all cell lines of CRC examined in this study. Overexpression of XBP-1 in SW480 cells promoted the invasion of cells, and this increase in tumor cell invasion was inhibited by inhibition of XBP-1 using small interfering RNA molecules (siRNA). In addition, results indicated that overexpression of XBP-1 in SW480 cells induced the level of Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) and inhibition of XBP-1 significantly decreased expression of VEGFR2, showing that XBP-1 is working upstream of VEGF-R2. This study demonstrated that pretreatment of HCT116 cells with ER stress inducers such as Tunicamycin (TM) decreased 5-FU-induced-apoptosis. The results are strongly suggestingthat XBP-1 promoted the invasion of colorectal cancer both in vitro and in vivo. Overexpression of XBP-1 cells enhanced VEGFR2 levels and could be responsible for CRC cell metastasis.
Autoren-Porträt von Ayed Abushbak
Abushbak, AyedDr. Ayed Abushbak (Bsc Pharmacy- Msc Clinical Pharmacy) obtained a master's degree in Clinical Pharmacy from Jordan University of Science and Technology JUST -Jordan. Currently Dr. Ayed is working in Indonisean Hospital at Gaza. His research interest is in Colorectal Cancer and Molecular oncology.
Bibliographische Angaben
- Autor: Ayed Abushbak
- 2019, 92 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 6139984025
- ISBN-13: 9786139984022
Sprache:
Englisch
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