Tolerance Inducing Effects of CMV Hyperimmunoglobulin Containing Drugs
(Sprache: Englisch)
Cytomegalovirus hyperimmunoglobulin (CMVIg) containing drugs are routinely administered in solid organ transplantation for prophylaxis against CMV disease. Yet little is known about their influence on transplant relevant immune functions.The aim of this...
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Cytomegalovirus hyperimmunoglobulin (CMVIg) containing drugs are routinely administered in solid organ transplantation for prophylaxis against CMV disease. Yet little is known about their influence on transplant relevant immune functions.The aim of this work was to evaluate the effect of CMVIg on cellular immunity in vitro and to define their role in tolerance inducing mechanisms. Our results show that CMVIg induce immunological features on leukocytes in vitro, which are known to be related to tolerance induction in vivo. These observations extend the current concept of CMVIg as passive CMV prophylaxis to a therapeutic drug compound capable to reduce allogeneic immune response.
Autoren-Porträt von Konrad Hoetzenecker
Hoetzenecker, KonradKonrad Hoetzenecker works at the Department of Surgery, Medical University of Vienna. His research projects cover immunological processes in cardiothoracic surgery with an emphasis on mechanisms of rejection and tolerance in heart and lung transplantation. His results are frequently published in high rank international journals.
Bibliographische Angaben
- Autor: Konrad Hoetzenecker
- 2008, 68 Seiten, Maße: 15 x 22 cm, Kartoniert (TB), Englisch
- Verlag: VDM Verlag Dr. Müller e.K.
- ISBN-10: 3639040422
- ISBN-13: 9783639040425
Sprache:
Englisch
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