Translation and Its Regulation in Cancer Biology a. Medicine
(Sprache: Englisch)
This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the...
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Klappentext zu „Translation and Its Regulation in Cancer Biology a. Medicine “
This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development.Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the translation machinery and its regulation in norm and cancer. Later chapters characterize etiological and pathogenetic roles that translation plays in specific cancer types. Various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery and its control in cancer are discussed. Readers will discover the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology.The chapters and the numerous illustrations included here were contributed by expert scientists and clinicians from renowned academic and clinical establishments in Canada, the United States of America, the United Kingdom, Italy, France, Belgium, Spain, Germany and Australia.The book conveys information and knowledge that may interest a broad range of students and scholars ranging from basic scientists to clinicians and drug developers seeking to better understand the protein synthesis and its aberrations in cancer biology and cancer medicine.
Inhaltsverzeichnis zu „Translation and Its Regulation in Cancer Biology a. Medicine “
Preface1 Introduction
PART I. TRANSALATION MACHINERY IN CANCER
2 Mechanism of Translation in Eukaryotes
3 Diverse Mechanisms of Translation Regulation and Their Role in Cancer
4 eIF4E and Its Binding Proteins
5 RNA Helicases and Their Cofactors
6 PDCD4
7 eIF4G
8 eIF3
9 The eIF2 Complex and eIF2a
10 eIF5A
11 eIF6
12 Translation Elongation
13 Ribosomes
14 Current and Emerging Therapies Targeting Translation
PART II. REGULATION OF TRANSLATION BY SIGNALING PATHWAYS IN CANCER
15 mTOR and Regulation of Translation
16 Ribosomal Protein S6 and S6 Kinases
17 eIF4E Phosphorylation Downstream of MAPK Pathway
PART III. CELL FATE AND TRANSLATION IN CANCER
18 Translational Control of Cell Proliferation and Viability in Normal and Neoplastic Cells
19 Translation and Apoptosis in Cancer
20 Translation in Cancer at Hypoxia
PART IV. TRANSLATION AND ITS REGULATION BY CANCER TYPES
21 Melanoma and Non-Melanoma Skin Cancers
22 Sarcomas
23 Hematological Malignancies and Premalignant Conditions24 Brain Tumors
25 Head and Neck Cancers
26 Breast Cancer
27 Cancers of the Respiratory System
28 Gastric and Esophageal Cancers
29 Colorectal Cancers
30 Hepatic, Pancreatic and Biliary Cancers
31 Pancreatic Neuroendocrine Tumors
32 Gynecologic Cancers
33 Prostate Cancer
34 Cancers of the Urinary System
List of Abbreviations
Bibliographische Angaben
- XXXIV, 697 Seiten, 47 farbige Abbildungen, 47 Schwarz-Weiß-Abbildungen, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben: Armen Parsyan
- Verlag: Springer Netherland
- ISBN-10: 9401790779
- ISBN-13: 9789401790772
- Erscheinungsdatum: 27.10.2014
Sprache:
Englisch
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