Venom Genomics and Proteomics
(Sprache: Englisch)
This handbook offers a comprehensive overview of toxinology. It covers all areas of toxinology, including topics like bioterrorism, toxin evolution and toxin based drug development.
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This handbook offers a comprehensive overview of toxinology. It covers all areas of toxinology, including topics like bioterrorism, toxin evolution and toxin based drug development.
Klappentext zu „Venom Genomics and Proteomics “
This volumeprovides the reader with recent advances in the fields of molecular toxinology,the biotechnological applications of venom toxins, and antivenom production.The content of the twenty chapters of Venom Genomics and Proteomicsillustrates not only the enormous progress made since the implementation ofomics technologies in the field of toxinology, but one also realizes the roadstill ahead to reach a holistic view of venomous systems. Advancement inhigh-throughput technologies in the field of venomics has resulted in theability to generate comprehensive venom profiles for many species. However,research on snake genomes is still in its infancy, although such studies areeagerly awaited to gain insights into the evolutionary history of snake venomproteins, including the mechanisms that originated venom and the regulation oftoxin expression. Fortunately, this objective is also at the reach of currentomic technologies. Therefore it would not be unrealistic to predict a brightnear future to the field of molecular toxinology.
VenomGenomics and Proteomics covers research into the venom of scaled reptiles (lizards andsnakes), scorpions, spiders, ants and platypuses. Special consideration isgiven to a number of observations made in the area of snake venom and in theapplication of advanced genomics and proteomics techniques on a variety ofvenom samples. The final chapters give some insight into the potential clinicaluses of venom derivatives and into the importance and challenges faced in theproduction and quality control of antivenoms.
Inhaltsverzeichnis zu „Venom Genomics and Proteomics “
Deadly Innovations: Unraveling the Molecular Evolution of AnimalVenoms.- Squamate Reptile Genomics and Evolution.- Venoms of Colubrids.- Phylogeneticsof Scorpions of Medical Importance.- Scorpion Venom Gland Transcriptomics andProteomics: An Overview.- Brown Spider Venom: The Identification andBiotechnological Potential of Venom Toxins.- Venom Toxins of Fire Ants.- ThePlatypus: A Venomous Mammal.- Structure-Function Relationship of ModularDomains of P-III Class.- Snake Venom Metalloproteinases.- BiologicalActivities and Assays of the Snake Venom Metalloproteinases (SVMPs).- Three-DimensionalStructures and Mechanisms of Snake Venom Serine Proteinases,Metalloproteinases, and Phospholipase A2s.- Structure-Function Relationship inHeterodimeric Neurotoxin PLA2s from Viperidae Snakes Inhabiting Europe, SouthAmerica, and Asia.- Snake Venom Phospholipase A2: Evolution and Diversity. - AutomatedMass Fingerprinting of Venoms in Nanogram Range: Review of Technology.- SnakeVenom Peptidomics.- Snake Venom Proteopeptidomics: What Lies Behind theCurtain.- Shotgun Approaches for Venom Analysis.- Purinergic Mechanisms ofPrey Acquisition by Venomous Organisms.- Applications of Snake Toxins inBiomedicine.- Industrial Production and Quality Control of Snake Antivenoms.
Autoren-Porträt
Prof P. Gopalakrishnakone is a world leader in the characterization of the structure and function of animal and plant toxins and chemical poisons, which contain highly specific and biologically active components. He has contributed significantly to the body of knowledge regarding the anatomy of snake venom glands and the development of drug candidates from animal toxins. Prof Gopal pioneered the development of the NUS Venom and Toxin Research Programme, which has put NUS at the forefront of toxin research internationally. The technology platform that has been built over the years under the Venom and Toxin Research Programme, coupled with its extensive library of protein and peptides, has enabled Prof Gopal and his team to complete the discovery process of lead candidates in time and to transfer valuable supplementary information to the next discovery steps involving profiling and optimization of lead candidates. The objective is to characterize the venom components and natural toxins at a molecular level and identify promising compounds amenable to the development of novel human therapeutics. Prof Gopal's lab has identified over twenty peptides with unique medical indications from venom-based proteins with some already under development as therapeutics.Prof Gopal's research studies includes structure function studies (toxin detection, biosensors, antitoxins and neutralization factors), toxicogenomics and expression studies, antimicrobial peptides from venoms and toxins and PLA2 inhibitors as potential drug candidate for inflammatory diseases. The techniques he employs include quantum dots to toxinology, computational biology, microarrays and protein chips. He has patented analgesic peptide, anti inflammatory peptide as well as anti rheumatoid arthritis peptides. He is exploring various possibilities of delivery systems for these peptides to target sites and administration of these peptides orally, transdermally, ocular and injections.
Prof Gopal has
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over 100 international peer-reviewed papers in venom and toxin research, drug discovery, biosensors, and toxinogenomics. His research awards include the Outstanding University Researcher Award from the National University of Singapore (1998); Ministerial Citation, NSTB Year 2000 Award in Singapore; and the Research Excellence Award from the Faculty of Medicine, National University of Singapore (2003). His awards in teaching include, Faculty Teaching Excellence Award 2003/4 & NUS Annual Teaching Excellence Award 2003/4. He also received the Faculty Teaching Excellence Award in 2009/10 and the Annual Teaching Excellence Award, NUS FOR 2009/10. He is the President of International Society on Toxinology till 2012, and is a member of the editorial board of Toxicon, the official journal of the International Society on Toxinology.
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Bibliographische Angaben
- 2016, 1st ed., 454 Seiten, mit farbigen Abbildungen, Maße: 15,9 x 24,1 cm, Gebunden, Englisch
- Herausgegeben:Gopalakrishnakone, P.; Calvete, Juan J.
- Herausgegeben: P. Gopalakrishnakone, Juan J. Calvete
- Verlag: Springer Netherlands
- ISBN-10: 9400764154
- ISBN-13: 9789400764156
- Erscheinungsdatum: 14.01.2016
Sprache:
Englisch
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