ADME Processes in Pharmaceutical Sciences (PDF)
Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. As an introduction...
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Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. As an introduction oriented to pharmacy students, it is also written for scientist from different fields outside of pharmaceutics. (e.g. material scientist, material engineers, medicinal chemists) who might be working in a positions in pharmaceutical companies or whose work might benefit from basic training in the ADME concepts and some biological background.
Pedagogical features such as objectives, keywords, discussion questions, summaries and case studies add valuable teaching tools. This book will provide not only general knowledge on ADME processes but also an updated insight on some hot topics such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers (nanopharmaceuticals), in vitro and in vivo bioequivalence studies, biopharmaceuticals, pharmacogenomics, drug-drug and food-drug interactions, and in silico and in vitro prediction of ADME properties. In comparison with other similar textbooks, around half of the volume would be focused on the relationship between expanding scientific fields and ADME processes. Each of these burgeoning fields has a separate chapter in the second part of the volume, and was written with leading experts on the correspondent topic, including scientists and academics from USA and UK (Duquesne University School of Pharmacy, Indiana University School of Medicine, University of Utah College of Pharmacy, University of Maryland, University of Bath).
Additionally, each of the initial chapters dealing with the generalities of drug absorption, distribution, metabolism and excretion would include relevant, classic examples related to each topic with appropriate illustrations (e.g. importance of active absorption of levodopa, implications in levodopa administration, drug drug interactions and food drug interactions emerging from the active uptake; intoxication with paracetamol as a result of glutathione depletion, CYP induction and its relationship with acute liver failure caused by paracetamol, etc).
ADME Processes and Pharmaceutical Sciences is written as a core textbook for ADME processes, pharmacy, pharmacokinetics, drug delivery, biopharmaceutics, drug disposition, drug design and medicinal chemistry courses.
Pablo Alejandro Mauricio Quiroga is a Pharmacist and has Bachelor in Pharmaceutical Sciences from the Faculty of Exact Sciences of the University of La Plata (UNLP). University Expert in Toxicology and Master of Science in Toxicology of the University of Seville, Spain. He is a Full Professor of the Chairs of Quality Control of Drugs and Pharmaceutical Toxicology of the Faculty of Exact Sciences of the UNLP. Chief of Pharmacological Research Department - Laboratorios Bagó S.A. Member of the Council of Experts of Argentinean Pharmacopoeia. Co- Editor of The E-Books: Pharmaceutical Analysis (2013), and Biopharmaceutical Processes (2016)- University of La Plata Publishing - EDULP. Co-author of several scientific publications. External reviewer of the UBACYT 2014-2017 Research Projects-UBA (University of Buenos Aires). Member of American Association of Pharmaceutical Scientists (AAPS) and the Argentinean Association of Industrial Pharmacy and Biochemistry (SAFYBI). Workshop Co-Chairs and Speaker "Implementation of Biowaivers based on the Biopharmaceutics Classification System"- held by the Focus Group on Biopharmaceuticals Classification System (BCS) and Biowaivers -International Pharmaceutical Federation (FIP) and Faculty of Exact Sciences - UNLP. Workshop Member of the Organizing Committee of "Dissolution Testing and Bioequivalence" held by American Association of Pharmaceutical Scientists (AAPS) and Faculty of Exact Sciences - UNLP.
- 2018, 1st ed. 2018, 362 Seiten, Englisch
- Herausgegeben: Alan Talevi, Pablo A. M. Quiroga
- Verlag: Springer-Verlag GmbH
- ISBN-10: 3319995936
- ISBN-13: 9783319995939
- Erscheinungsdatum: 30.11.2018
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
- Dateiformat: PDF
- Größe: 8.31 MB
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