Alternatives for Dermal Toxicity Testing (PDF)
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This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol, possible adaptations, and challenges and opportunities. The closing section addresses exploratory areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, the use of alternative methods for infections and inflammatory diseases, novel complex skin models, and high-throughput screening techniques.
Dermal toxicity is an area in which alternatives to the use of animal testing have already gained scientific, industrial, and regulatory acceptance. Practitioners and researchers alike will find Alternatives for Dermal Toxicity Testing to be an ideal source of reliable, up-to-date information on all aspects of the available test methods and likely future directions.
Howard I. Maibach, MD, is Professor of Dermatology in the School of Medicine, University of California, San Francisco. He is a leading authority in the fields of dermatotoxicology and dermatopharmacology, in which, over several decades, he has conducted much original research relating to skin diseases and the development of skin-related products. He has written very extensively, with a total of more than 2,000 publications as lead or co-author and over 80 textbooks. Professor Maibach has served on the editorial boards of more than 30 scientific journals and is a member of many professional societies, including the American Academy of Dermatology and the International Commission on Occupational Health. He is a consultant to government agencies, universities, and industry. He has been the recipient of numerous honors, both in the United States and overseas.
Erwin van Vliet, PhD, has more than 10 years
- 2017, 1st ed. 2017, 592 Seiten, Englisch
- Herausgegeben: Chantra Eskes, Erwin van Vliet, Howard I. Maibach
- Verlag: Springer-Verlag GmbH
- ISBN-10: 3319503537
- ISBN-13: 9783319503530
- Erscheinungsdatum: 21.11.2017
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- Größe: 11 MB
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