Apoliprotein B, A1 and Diabetes Type 2 (PDF)

Scientific Essay from the year 2008 in the subject Medicine - Internal Medicine, , language: English, abstract: This paper examines the relations between Apoliprotein B, Apoliprotein A1 and Diabetes Type 2.

Diabetes mellitus refers to a group of metabolic disorders of multiple aetiology and characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.

The effects of diabetes mellitus include long-term damage, dysfunction and failure of various organs. Diabetes mellitus may present with characteristic symptoms such as thirst, polyuria, blurring of vision, and weight loss. In its most severe forms, ketoacidosis or a non-ketotic hyperosmolar state may develop and lead to stupor, coma and in absence of effective treatment, death.

Often symptoms are not severe, or may be absent, and consequently hyperglycaemia sufficient to cause pathological and functional changes may be present for a long time before the diagnosis is made. It is a major health problem in all nations. Diabetes is the single, most important metabolic disease, widely recognized as one of the leading causes of death and disability worldwide.

This devastating disease can affect nearly every system in the body. It can cause blindness, lead to end stage renal disease, lower extremity amputations and increase the risk for stroke, ischemic heart disease, peripheral vascular disease, and neuropathy. Diabetic macro and microvascular complications are resulting in increased disability and enormous health care costs.