Biology of IGF-1 (PDF)
Its Interaction with Insulin in Health and Malignant States
(Sprache: Englisch)
An invaluable book containing a series of interdisciplinary
discussions between clinical and basic scientists. Biology
of IGF-1: Its interaction with insulin and health and malignant
states focuses on key issues such as:
* the definition of danger...
discussions between clinical and basic scientists. Biology
of IGF-1: Its interaction with insulin and health and malignant
states focuses on key issues such as:
* the definition of danger...
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Produktinformationen zu „Biology of IGF-1 (PDF)“
An invaluable book containing a series of interdisciplinary
discussions between clinical and basic scientists. Biology
of IGF-1: Its interaction with insulin and health and malignant
states focuses on key issues such as:
* the definition of danger zones
* the development of methods for early recognition of malignant
states linked to IGF-1 and/or insulin
* possible approaches to preventative intervention
* the relevance in this field of research to the development of
novel therapeutic approaches to treating certain cancers.
discussions between clinical and basic scientists. Biology
of IGF-1: Its interaction with insulin and health and malignant
states focuses on key issues such as:
* the definition of danger zones
* the development of methods for early recognition of malignant
states linked to IGF-1 and/or insulin
* possible approaches to preventative intervention
* the relevance in this field of research to the development of
novel therapeutic approaches to treating certain cancers.
Inhaltsverzeichnis zu „Biology of IGF-1 (PDF)“
Chair's Introduction (Leroith). Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse (Yakar et al). Physiology of the IGF system (Holly). Molecular basis of insulin action (Zick). IGF-1 and insulin as growth hormones (Laron). Insulin-like growth factors and neoplasia (Pollak). Loss of IGF2 imprinting: mechanisms and consequences (Ohlsson). Insulin and IGF-1 receptor trafficking and sginalling (Foti et al). The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb (Nobukini and Thomas). Structural biology of insulin and IGF-1 receptors (De Meyts et al). Genetic blockade of the insulin-like growth factor-I receptor for human malignancy (Adachi et al). IGF-1 and prostate cancer (Roberts Jr.). IGF-1 and breast cancer (Lonning and Helle). IGFBPs and cancer (Fang et al). The IGF receptor as anti-cancer treatment target (Macaulay). Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence (Kaaks). Final discussion. Index of contributors. Subject index.
Autoren-Porträt
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
Bibliographische Angaben
- 2005, 1. Auflage, 288 Seiten, Englisch
- Herausgegeben: Gregory R. Bock, Jamie A. Goode
- Verlag: John Wiley & Sons
- ISBN-10: 0470869992
- ISBN-13: 9780470869994
- Erscheinungsdatum: 10.06.2005
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- Größe: 4.09 MB
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Englisch
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