Chemistry and Biochemistry of Oxygen Therapeutics (PDF)

Human blood performs many important functions including defence
against disease and transport of biomolecules, but perhaps the most
important is to carry oxygen - the fundamental biochemical
fuel - and other blood gases around the cardiovascular system.
Traditional therapies for the impairment of this function, or the
rapid replacement of lost blood, have centred around blood
transfusions. However scientists are developing chemicals (oxygen
therapeutics, or "blood substitutes") which have the
same oxygen-carrying capability as blood and can be used as
replacements for blood transfusion or to treat diseases where
oxygen transport is impaired.

Chemistry and Biochemistry of Oxygen Therapeutics: From
Transfusion to Artificial Blood links the underlying
biochemical principles of the field with chemical and
biotechnological innovations and pre-clinical development.

The first part of the book deals with the chemistry,
biochemistry, physiology and toxicity of oxygen, including chapters
on hemoglobin reactivity and regulation; the major cellular and
physiological control mechanisms of blood flow and oxygen
delivery; hemoglobin and myoglobin; nitric oxide and
oxygen; and the role of reactive oxygen and nitrogen species in
ischemia/reperfusion Injury.

The book then discusses medical needs for oxygen supply,
including acute traumatic hemorrhage and anemia; diagnosis and
treatment of haemorrhages in "non-surgical" patients; management of
perioperative bleeding; oxygenation in the preterm neonate;
ischemia

normobaric and hyperbaric oxygen therapy for ischemic stroke and
other neurological conditions; and transfusion therapy in beta
thalassemia and sickle cell disease

Finally "old"and new strategies for oxygen supply
are described. These include the political, administrative and
logistic issues surrounding transfusion; conscientious
objection in patient blood management; causes and consequences of
red cell incompatibility; biochemistry of red blood cell
storage; proteomic investigations on stored red blood cells;
red blood cells from stem cells; the universal red blood
cell; allosteric effectors of hemoglobin; hemoglobin-based
oxygen carriers; oxygen delivery by natural and artificial
oxygen carriers; cross-linked and polymerized hemoglobins as
potential blood substitutes; design of novel pegylated hemoglobins
as oxygen carrying plasma expanders; hb octamers by introduction of
surface cysteines; hemoglobin-vesicles as a cellular type
hemoglobin-based oxygen carrier; animal models and oxidative
biomarkers to evaluate pre-clinical safety of extracellular
hemoglobins; and academia - industry collaboration in blood
substitute development.

Chemistry and Biochemistry of Oxygen Therapeutics: From
Transfusion to Artificial Blood is an essential reference for
clinicians, haematologists, medicinal chemists, biochemists,
molecular biologists, biotechnologists and blood substitute
researchers.