Chemistry of Protein and Nucleic Acid Cross-Linking and Conjugation (PDF)
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An overview of the chemical principles underlying the processes of cross-linking and conjugation, this book offers a thorough list of cross-linking reagents published in the literature since the first edition, covering monofunctional, homobifunctional, heterobifunctional, multifunctional, and zero-length cross-linkers. It reviews of the use of these reagents in studying protein tertiary structures, geometric arrangements of subunits within complex proteins and nucleic acids, near-neighbor analysis, protein-to-protein or ligand-receptor interactions, and conformational changes of biomolecules. Finally, it discusses the application of immunoconjugation for immunoassays, immunotoxins for targeted therapy, microarray technology for analysis of various biomolecules, and solid state chemistry for immobilizations.
Dr. Wong has published extensively in various scientific journals in the area of enzymology and clinical chemistry. He has received numerous honors and awards and has been active in various professional societies.
David M. Jameson, Ph.D., joined the Department of Cell and Molecular Biology at the John A. Burns School of Medicine at the University of Hawaii in 1989, where he is presently a full professor. Before moving to Hawaii he was on the faculty of the Pharmacology Department at the University of Texas Southwestern Medical School in Dallas.
Dr. Jameson received his BS in chemistry from Ohio State University in 1971 and his PhD in biochemistry from the University of Illinois at Urbana-Champaign in 1978. His thesis advisor was Gregorio Weber, who laid the foundations of modern fluorescence spectroscopy. Dr. Jameson carried out postdoctoral research at the Universite Paris-Sud at Orsay, France before returning to the University of Illinois for a postdoctoral period in Gregorio Weber's laboratory. In 1983, he joined the Pharmacology Department at the University of Texas Southwestern Medical Center at Dallas as an assistant profess
- Autoren: Shan S. Wong , David M. Jameson
- 2011, 2. Auflage, 622 Seiten, Englisch
- Verlag: Taylor & Francis
- ISBN-10: 1420007645
- ISBN-13: 9781420007640
- Erscheinungsdatum: 10.10.2011
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- Dateiformat: PDF
- Größe: 45 MB
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