Chemoattractant Ligands and Their Receptors (PDF)

Richard Horuk, Ph.D., is a Senior Scientist in the Department of Immunology at Berlex BioSciences, Richmond, California. Dr. Horuk received his B.Sc. Degree in Applied Biology from Trent Polytechnic, Nottingham, U.K., in 1977 and his Ph.D. Degree in Biochemistry in 1980 from Birkbeck College, University of London, U.K. He was a Postdoctoral fellow from 1981 to 1983 working in the laboratory of Dr. Martin Rodbell at the National Institutes of Health, Bethesda, Maryland. In 1983 he joined Dr. Jerrold Olefsky's laboratory at the University of California San Diego to pursue further studies on insulin action, after which he was appointed as an assistant researcher. In 1986 Dr. Horuk was appointed Principal Scientist at the Dupont Company in Glenolden, Pennsylvania, where he undertook research on interleukin-1 receptors and was the first to discover both the type II IL-1 receptor and the soluble IL-1 receptor. From 1991 to 1994 Dr. Horuk was in the Department of Protein Chemistry, Genentech, California. Here Dr. Horuk started a research program centered on chemokines and their receptors and was the first to discover that the Duffy Antigen, a portal of entry for the malarial parasite Plasmodium vivax, was also a chemokine receptor. Dr. Horuk joined Berlex BioSciences in 1994 and presently leads a major program on chemokine receptor research. Dr. Horuk is a member of the American Society of Biochemistry and Molecular Biology, the American Association of Immunologists, the Protein Society, the International Cytokine Society, and the American Association for the Advancement of Science. Dr. Horuk has presented numerous invited lectures at international and national meetings on chemokines and has published more than 80 research papers. His current research interests involve the role of chemokines in disease and the implementation of various therapeutic interventions.