Cracking the Code (PDF)

Acknowledgements ix Introduction xi Chapter One Transformational Technologies 1 Futurists and Scientists Look into the Future 1 The Convergence of Technology and Biology 13 Chapter Two The Evolution of Medicine and the Emergence of Biopharma 23 From Atoms to Cells to Living Organisms 24 The History of the Pharmaceutical Industry 36 Chapter Three The Drug Industry - Reinventing the Model 55 Big Pharma, Biopharma 59 Drug Patents 73 The Path to Riches: FDA Approval 79 In Summary 84 Chapter Four Curing Disease - Promising Prospects in the Main Therapeutic Areas 87 Cancer - Step by Step, Being Beaten 89 Infectious Diseases: New Antibiotics, Hepatitis and HIV Drugs Make for a Fast-growing Sector 107 Obesity and its Evil Sisters: Type 2 Diabetes and Kidney Disease 118 The Heart of the Matter - Biggest Killer on the Prowl 128 Fading into the Night - Neurodegeneration, Rheumatology and Multiple Sclerosis 132 Respiratory Disease - New Drugs: A Breath of Fresh Air 143 Rare Diseases and Rare Profits 146 Drugs for Pain and for the Central Nervous System 150 The Best of the Rest - Ophthalmology, Dermatology, Gastrointestinal and Bone Disease 153 Chapter Five Turning Back the Clock - Stem Cells, Genomics, Gene Therapy and Regeneration 157 Stem Cells 166 Gene Therapy and Nano Medicine 170 Organ Growth in and out of the Body 178 Chapter Six Demographic Changes 181 The Working Age Labour Pool in the World is Shrinking 191 Can Immigration Solve the Labour Shortage in the Developed World? 193 The Social Impact of an Ageing Population 195 The United States is the Best Positioned Developed Country 196 Support Ratios Have Been Plummeting 197 China's Grey Future 198 What Can Governments Do To Avoid Their Country Becoming a Nursing Home? 200 Chapter Seven Bioscience's Disruptive Influences 205 Insurance and Healthcare 206 Real Estate 210 Politics 211 Geopolitics 211 Retail Goods and Services 212 The Food Industry 213 The Investment Industry 214 The Law 215 Shortage of Young People in

JIM MELLON is an investor with interests in several industries. He is founder of a listed fund management company, Charlemagne Capital, and an Asian mining group, Regent Pacific. In addition, Jim is a director of Manx Financial Group - an Isle of Man based bank, and a controlling shareholder of Speymill - a property business, and Webis Holdings. He is a co-founder of Uramin and West African Minerals Resources, both mining groups. The Burnbrae Group, his private company, is a substantial landlord in Germany and in the Isle of Man, and he also owns the hotel chain Sleepwell Hotels. Jim spends most of his time working on start-up ideas and on investing. Jim lives in the Isle of Man, Brussels and Ibiza. He is an honorary fellow of Oriel College, Oxford.

AL CHALABI is an entrepreneur with a diverse professional background who started his career as a systems engineer in Canada. Following this, he worked as a management consultant advising corporations across a number of industries, and more recently as the CFO for a real estate investment company. He currently runs CASP-R, a firm he co-founded in 2008 to provide independent real estate research and advisory services to investors and corporate occupiers across the Asia-Pacific region. He lives in Hong Kong with his partner Fiona and two young children.

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