Crystallization of Organic Compounds (PDF)

Filled with industrial examples emphasizing the practical
applications of crystallization methodologies

Based on the authors' hands-on experiences as process engineers
at Merck, Crystallization of Organic Compounds guides
readers through the practical aspects of crystallization. It uses
plenty of case studies and examples of crystallization processes,
ranging from development through manufacturing scale-up. The book
not only emphasizes strategies that have been proven successful, it
also helps readers avoid common pitfalls that can render standard
procedures unsuccessful.

The goal of this text is twofold:

* Build a deeper understanding of the fundamental properties of
crystallization as well as the impact of these properties on
crystallization process development.

* Improve readers' problem-solving abilities by using actual
industrial examples with real process constraints.

Crystallization of Organic Compounds begins with detailed
discussions of fundamental thermodynamic properties, nucleation and
crystal growth kinetics, process dynamics, and scale-up
considerations. Next, it investigates modes of operation, including
cooling, evaporation, anti-solvent, and reactive crystallization.
The authors conclude with special applications such as ultrasound
in crystallization and computational fluid dynamics in
crystallization. Most chapters feature multiple examples that guide
readers step by step through the crystallization of active
pharmaceutical ingredients (APIs).

With its focus on industrial applications, this book is
recommended for chemical engineers and chemists who are involved
with the development, scale-up, or operation of crystallization
processes in the pharmaceutical and fine chemical industries.