Discovering and Developing Molecules with Optimal Drug-Like Properties / AAPS Advances in the Pharmaceutical Sciences Series Bd.15 (PDF)
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This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists of fourteen chapters with an underlying theme of early collaborative opportunities between pharmaceutical and discovery sciences. The book explores the practical realities of performing physical pharmaceutical and biopharmaceutical research in the context of drug discovery with short timelines and low compound availability. Chapters cover strategies and tactics to enable discovery as well as predictive approaches to establish, understand and communicate risks in early development. It also examines the detection, characterization and assessment of risks on the solid state properties of advanced discovery and early development candidates, highlighting the link between solid state propertiesand critical development parameters such as solubility and stability. Final chapters center on techniques to improve molecular solubilization and prevent precipitation, with particularly emphasis on linking physiochemical properties of molecules to formulation selection in preclinical and clinical settings.
Dr. Stephen R. Byrn is Charles B. Jordan Professor of Medicinal Chemistry in the Department of Industrial and Physical Pharmacy, Purdue University. Dr. Byrn set in motion the development of the field ofsolid state chemistry of drugs with his books and papers on the subject. He has also
Dr. Roy J. Haskell is a Research Fellow in the Discovery Pharmaceutics group of Bristol-Myers Squibb, where he is engaged in discovery support as well as the design and characterization of novel formulations. He received a Ph.D. in Analytical Chemistry from the University of Wisconsin-Madison. He joined The Upjohn Company and worked in the area of protein biophysics. As part of Pharmacia, his focus transitioned to formulating poorly soluble molecules and characterizing the formulations by which such compounds are delivered. Dr. Haskell's research interests include design and characterization of colloidal formulations, predictive modeling of physicochemical properties, sizing submicron particles, aggregation/precipitation mechanisms, the role of solubility and supersaturation in oral absorption, and the use nanotechnology in drug discovery and development. Dr. Haskell is the author of three patents and more than 30 publications and presentations.
Dr. Thomas E. Prisinzano received his Ph.D. in Pharmaceutical Sciences from the School of Pharmacy, Virginia Commonwealth University, in Richmond, Virginia. He was an Intramural Research Training Award Fellow in the National Institute of Diabetes and Digestive and Kidney Diseases in Bethesda, Maryland, and is currently Professor and Chair of the Department of Medicinal Chemistry at the University of Kansas. His research focuses on the development of novel agents to treat pain, substance abuse and other CNS disorders through the identification, structure elucidation, and optimization of natural products. Dr. Prisinzano has received a number of awards including the D. John Faulkner Travel Award from the American Society of Pharmacognosy, the Jack L. Beal Award from the Journal of Natural Products, the Matt Suffness (Young Investigator) Award from the American Society of Pharmacognosy, the Joseph Cochin Young Investigator Award from the College on Problems of Drug Dependence, and the David W. Robertson Award for Excellence in Medicinal Chemistry from the American Chemical Society.
- 2014, 2015, 511 Seiten, Englisch
- Herausgegeben: Allen C Templeton, Stephen R. Byrn, Roy J Haskell, Thomas E. Prisinzano
- Verlag: Springer-Verlag GmbH
- ISBN-10: 1493913999
- ISBN-13: 9781493913992
- Erscheinungsdatum: 31.10.2014
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- Größe: 11 MB
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