Enzyme Technologies / Chemical Biology of Enzymes for Biotechnology and Pharmaceutical Applications (PDF)

An authoritative review of the latest developments in the
chemical biology of enzymes

In the first decade of the twenty-first century, enzymes and
their multiple applications have played a critical role in the
discovery and development of many new therapeutic agents.This book
is a coordinated compilation of research expertise and current
opinion uniquely focused on enzymes and their properties and
applications.

Compiled by editors with a combined pharmaceutical experience of
over sixty years, the text provides in-depth reviews of recent
developments in selective topics on biosynthesis, biocatalysis, and
chemical biology of enzymes as it applies to drug discovery,
development, and manufacture.

The first in a multi-part series on enzymes, this volume
features three sections:

* New Approaches to Find and Modify Enzymes describes the emerging
field of metagenomics, presents the practical applications of
directed evolution to enzymes and pathways, and explores approaches
for the discovery and design of biocatalysts

* Biocatalytic Applications reviews specific applications of
different reactions in producing active pharmaceutical ingredients
and surveys recent developments employing enzymes in organic
synthesis

* Biosynthetic Applications goes over successful drug discoveries
and developments by combinatorial biosynthesis and reviews the
application of combinatorial biosynthesis among multiple compatible
hosts

These timely discussions, which cover everything from chemical
biology of enzymes, to the redesign of binding and catalytic
specificities of enzymes, make this volume a valuable tool for
keeping up to date. As such, it is an important read for
researchers, students, and professors in the study of
biotechnology, life sciences, biochemistry, enzymology, medicinal
chemistry, and natural products.