Experimental Liver Transplantation (PDF)

Naoshi Kamada, M.D., Ph.D. (Cantab) is Director of Experimental Surgery at the National Children's Medical Research Center, Tokyo, Professor of Kobe University School of Medicine, Japan, and Visiting Professor of Surgery, University of Cordoba, Spain. After reading Medical sciences in Japan, Professor Kamada was a research and clinical fellow in transplantation under Sir Roy Y. Calne in the Department of Surgery, University of Cambridge, England, Starting in 1977. He was then a research student at Trinity Hall, Cambridge, receiving his Ph.D. in 1982 for a dissertation on the subject of tolerance induced by liver transplantation in the rat. Since then, most of his research career has been spent in the Department of Surgery, University of Cambridge, England. In 1986 he assumed his present appointments in Japan. Most of Professor Kamada's research has been spent in the area of liver transplantation using rats. In 1979 he developed a technique using cuffs for orthotopic rat liver transplantation (OLT). Since then he has performed these operations in over 1300 cases. Using this rat model, he reported that liver transplants did not obey the normal rules of transplantation. His recent work has been concerned with mechanisms of tolerance and antigen-specific immunosuppression induced by OLT. He has published over 50 papers in immunology and surgical techniques. He was awarded with the Jean Morelle Prize from the La Fondation Jean Morelle, Brussels, Belgium, in 1982, and the Darlington Prize, Darlington, England, in 1987.