Gene Transcription (PDF)

Transcription is the focus of much cutting-edge research, as befits
its essential place in biology. The established link between
defects in gene transcription and many human disorders has fuelled
considerable activity in the biomedical arena, particularly cancer
research. This concentration of attention has uncovered a myriad of
factors involved in transcription and the literature is now rife
with jargon and complexity.

Gene Transcription: Mechanisms and Control aims to
demystify the subject for a non-expert audience, providing a guided
tour around the complex machinery of the transcriptional apparatus
and discussing how the various factors achieve their functions. By
focusing on general principles and illustrating these with a select
group of examples, many of which are linked to human diseases, the
author conveys the intricacies of transcriptional control in an
accessible manner.

With the first chapter presenting an overview of gene
expression, this is a 'stand-alone' text, ideal for advanced level
undergraduates and postgraduates in biology, biochemistry and
medical sciences. It will also appeal to research scientists who
require a broad current perspective on this rapidly moving and
complex field.

* * Provides a broad and accessible introduction to gene
transcription.

* * Up-to-date coverage of the major topics in a rapidly evolving
field.

* Illustrates the links between aberrant transcription and human
disease.

* Explains the jargon associated with transcription factors.